1or4
From Proteopedia
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'''Crystal Structure of HemAT sensor domain from B.subtilis in the cyano-liganded form''' | '''Crystal Structure of HemAT sensor domain from B.subtilis in the cyano-liganded form''' | ||
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[[Category: Jr., G N.Phillips.]] | [[Category: Jr., G N.Phillips.]] | ||
[[Category: Zhang, W.]] | [[Category: Zhang, W.]] | ||
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| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 04:10:54 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 01:10, 3 May 2008
Crystal Structure of HemAT sensor domain from B.subtilis in the cyano-liganded form
Overview
Much is now known about chemotaxis signaling transduction for Escherichia coli and Salmonella typhimurium. The mechanism of chemotaxis of Bacillus subtilis is, in a sense, reversed. Attractant binding strengthens the activity of histidine kinase in B. subtilis, instead of an inhibition reaction. The HemAT from B. subtilis can detect oxygen and transmit the signal to regulatory proteins that control the direction of flagella rotation. We have determined the crystal structures of the HemAT sensor domain in liganded and unliganded forms at 2.15 A and 2.7 A resolution, respectively. The liganded structure reveals a highly symmetrical organization. Tyrosine70 shows distinct conformational changes on one subunit when ligands are removed. Our study suggests that disruption of the symmetry of HemAT plays an important role in initiating the chemotaxis signaling transduction cascade.
About this Structure
1OR4 is a Single protein structure of sequence from Bacillus subtilis. Full crystallographic information is available from OCA.
Reference
Structure of the oxygen sensor in Bacillus subtilis: signal transduction of chemotaxis by control of symmetry., Zhang W, Phillips GN Jr, Structure. 2003 Sep;11(9):1097-110. PMID:12962628 Page seeded by OCA on Sat May 3 04:10:54 2008
