1orh

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[[Image:1orh.gif|left|200px]]
[[Image:1orh.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1orh |SIZE=350|CAPTION= <scene name='initialview01'>1orh</scene>, resolution 2.64&Aring;
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The line below this paragraph, containing "STRUCTURE_1orh", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Histone-arginine_N-methyltransferase Histone-arginine N-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.125 2.1.1.125] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= HRMT1L2 OR PRMT1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus])
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|DOMAIN=
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{{STRUCTURE_1orh| PDB=1orh | SCENE= }}
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|RELATEDENTRY=[[1or8|1OR8]], [[1f3l|1F3L]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1orh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1orh OCA], [http://www.ebi.ac.uk/pdbsum/1orh PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1orh RCSB]</span>
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}}
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'''Structure of the Predominant Protein Arginine Methyltransferase PRMT1'''
'''Structure of the Predominant Protein Arginine Methyltransferase PRMT1'''
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[[Category: Cheng, X.]]
[[Category: Cheng, X.]]
[[Category: Zhang, X.]]
[[Category: Zhang, X.]]
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[[Category: protein arginine methylation adomet-dependent methylation]]
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[[Category: Protein arginine methylation adomet-dependent methylation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 04:11:33 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:49:14 2008''
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Revision as of 01:11, 3 May 2008

Image:1orh.gif

Template:STRUCTURE 1orh

Structure of the Predominant Protein Arginine Methyltransferase PRMT1


Overview

PRMT1 is the predominant type I protein arginine methyltransferase in mammals and highly conserved among all eukaryotes. It is essential for early postimplantation development in mouse. Here we describe the crystal structure of rat PRMT1 in complex with the reaction product AdoHcy and a 19 residue substrate peptide containing three arginines. The results reveal a two-domain structure-an AdoMet binding domain and a barrel-like domain-with the active site pocket located between the two domains. Mutagenesis studies confirmed that two active site glutamates are essential for enzymatic activity, and that dimerization of PRMT1 is essential for AdoMet binding. Three peptide binding channels are identified: two are between the two domains, and the third is on the surface perpendicular to the strands forming the beta barrel.

About this Structure

1ORH is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

Structure of the predominant protein arginine methyltransferase PRMT1 and analysis of its binding to substrate peptides., Zhang X, Cheng X, Structure. 2003 May;11(5):509-20. PMID:12737817 Page seeded by OCA on Sat May 3 04:11:33 2008

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