1ork

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[[Image:1ork.jpg|left|200px]]
[[Image:1ork.jpg|left|200px]]
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{{Structure
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|PDB= 1ork |SIZE=350|CAPTION= <scene name='initialview01'>1ork</scene>, resolution 2.4&Aring;
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The line below this paragraph, containing "STRUCTURE_1ork", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=TNE:Tetracycline+Binding'>TNE</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=ATC:9-(N,N-DIMETHYLGLYCYLAMIDO)-6-DEOXY-6-DEMETHYL-TETRACYCLINE'>ATC</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE=
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|DOMAIN=
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{{STRUCTURE_1ork| PDB=1ork | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ork FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ork OCA], [http://www.ebi.ac.uk/pdbsum/1ork PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1ork RCSB]</span>
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}}
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'''TET REPRESSOR, CLASS D IN COMPLEX WITH 9-(N,N-DIMETHYLGLYCYLAMIDO)-6-DEMETHYL-6-DEOXY-TETRACYCLINE'''
'''TET REPRESSOR, CLASS D IN COMPLEX WITH 9-(N,N-DIMETHYLGLYCYLAMIDO)-6-DEMETHYL-6-DEOXY-TETRACYCLINE'''
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[[Category: Schnappinger, D.]]
[[Category: Schnappinger, D.]]
[[Category: Sum, P E.]]
[[Category: Sum, P E.]]
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[[Category: transcription regulation]]
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[[Category: Transcription regulation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 04:11:45 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:49:21 2008''
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Revision as of 01:11, 3 May 2008

Image:1ork.jpg

Template:STRUCTURE 1ork

TET REPRESSOR, CLASS D IN COMPLEX WITH 9-(N,N-DIMETHYLGLYCYLAMIDO)-6-DEMETHYL-6-DEOXY-TETRACYCLINE


Overview

The tetracycline analog 9-(N, N-dimethylglycylamido)-6-demethyl-6-deoxy-tetracycline (9glyTc) belongs to a new group of tetracyclines called glycylcyclines. They are strong antibiotics showing reduced sensitivity against the major tetracycline resistance mechanisms. We have determined the crystal structure of 9glyTc in complex with Tet repressor class D, TetR(D), at 2.4 A resolution. Sterical hindrance at the entrance of the tetracycline binding tunnel of TetR by the bulky and charged glycyl amido substituent interferes with conformational changes required for the mechanism of induction, and leads to decreased induction efficiency as observed for point mutations of amino acid residues located in the neighbourhood to the glycylamido moiety of bound 9glyTc.

About this Structure

1ORK is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Crystal structure of the tet repressor in complex with a novel tetracycline, 9-(N,N-dimethylglycylamido)- 6-demethyl-6-deoxy-tetracycline., Orth P, Schnappinger D, Sum PE, Ellestad GA, Hillen W, Saenger W, Hinrichs W, J Mol Biol. 1999 Jan 15;285(2):455-61. PMID:9878420 Page seeded by OCA on Sat May 3 04:11:45 2008

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