5o8o

From Proteopedia

(Difference between revisions)

Current revision

N. crassa Tom40 model based on cryo-EM structure of the TOM core complex at 6.8 A

5o8o, resolution 6.80Å

Structural highlights

5o8o is a 1 chain structure with sequence from Neurospora crassa. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	Electron Microscopy, Resolution 6.8Å
Experimental data:	Check to display Experimental Data
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

TOM40_NEUCR Channel-forming protein essential for import of protein precursors into mitochondria.^[1]

Publication Abstract from PubMed

The TOM complex is the main entry gate for protein precursors from the cytosol into mitochondria. We have determined the structure of the TOM core complex by cryoelectron microscopy (cryo-EM). The complex is a 148 kDa symmetrical dimer of ten membrane protein subunits that create a shallow funnel on the cytoplasmic membrane surface. In the core of the dimer, the beta-barrels of the Tom40 pore form two identical preprotein conduits. Each Tom40 pore is surrounded by the transmembrane segments of the alpha-helical subunits Tom5, Tom6, and Tom7. Tom22, the central preprotein receptor, connects the two Tom40 pores at the dimer interface. Our structure offers detailed insights into the molecular architecture of the mitochondrial preprotein import machinery.

Cryo-EM Structure of the TOM Core Complex from Neurospora crassa.,Bausewein T, Mills DJ, Langer JD, Nitschke B, Nussberger S, Kuhlbrandt W Cell. 2017 Aug 10;170(4):693-700.e7. doi: 10.1016/j.cell.2017.07.012. PMID:28802041^[2]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Ahting U, Thieffry M, Engelhardt H, Hegerl R, Neupert W, Nussberger S. Tom40, the pore-forming component of the protein-conducting TOM channel in the outer membrane of mitochondria. J Cell Biol. 2001 Jun 11;153(6):1151-60. PMID:11402060
↑ Bausewein T, Mills DJ, Langer JD, Nitschke B, Nussberger S, Kuhlbrandt W. Cryo-EM Structure of the TOM Core Complex from Neurospora crassa. Cell. 2017 Aug 10;170(4):693-700.e7. doi: 10.1016/j.cell.2017.07.012. PMID:28802041 doi:http://dx.doi.org/10.1016/j.cell.2017.07.012

1 Structural highlights
2 Function
3 Publication Abstract from PubMed
4 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/5o8o"

@@ Line 3: / Line 3: @@
 <SX load='5o8o' size='340' side='right' viewer='molstar' caption='[[5o8o]], [[Resolution|resolution]] 6.80&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[5o8o]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Chrysonilia_crassa Chrysonilia crassa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5O8O OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5O8O FirstGlance]. <br>
+<table><tr><td colspan='2'>[[5o8o]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Neurospora_crassa Neurospora crassa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5O8O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5O8O FirstGlance]. <br>
-</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5o8o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5o8o OCA], [http://pdbe.org/5o8o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5o8o RCSB], [http://www.ebi.ac.uk/pdbsum/5o8o PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5o8o ProSAT]</span></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 6.8&#8491;</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5o8o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5o8o OCA], [https://pdbe.org/5o8o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5o8o RCSB], [https://www.ebi.ac.uk/pdbsum/5o8o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5o8o ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/TOM40_NEUCR TOM40_NEUCR]] Channel-forming protein essential for import of protein precursors into mitochondria.<ref>PMID:11402060</ref>
+[https://www.uniprot.org/uniprot/TOM40_NEUCR TOM40_NEUCR] Channel-forming protein essential for import of protein precursors into mitochondria.<ref>PMID:11402060</ref>
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 21: / Line 22: @@
 __TOC__
 </SX>
-[[Category: Chrysonilia crassa]]
 [[Category: Large Structures]]
-[[Category: Bausewein, T]]
+[[Category: Neurospora crassa]]
-[[Category: Kuehlbrandt, W]]
+[[Category: Bausewein T]]
-[[Category: Mills, D J]]
+[[Category: Kuehlbrandt W]]
-[[Category: Nitschke, B]]
+[[Category: Mills DJ]]
-[[Category: Nussberger, S]]
+[[Category: Nitschke B]]
-[[Category: Cryo-em]]
+[[Category: Nussberger S]]
-[[Category: Mitochondria]]
-[[Category: Protein import]]
-[[Category: Protein transport]]
-[[Category: Tom-complex]]

5o8o

From Proteopedia

Current revision

N. crassa Tom40 model based on cryo-EM structure of the TOM core complex at 6.8 A

Structural highlights

Function

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

Personal tools

Navigation

Search

Toolbox