Tiotropium bromide
From Proteopedia
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Tiotropium is a [[Muscarinic acetylcholine receptor|muscarinic receptor]] antagonist, often referred to as an antimuscarinic or anticholinergic agent. Although it does not display selectivity for specific muscarinic receptors, when topically applied it acts mainly on M3 muscarinic receptors<ref name="a28">PMID:17127817</ref> located on smooth muscle cells and submucosal glands. This leads to a reduction in smooth muscle contraction and mucus secretion and thus produces a bronchodilatory effect. | Tiotropium is a [[Muscarinic acetylcholine receptor|muscarinic receptor]] antagonist, often referred to as an antimuscarinic or anticholinergic agent. Although it does not display selectivity for specific muscarinic receptors, when topically applied it acts mainly on M3 muscarinic receptors<ref name="a28">PMID:17127817</ref> located on smooth muscle cells and submucosal glands. This leads to a reduction in smooth muscle contraction and mucus secretion and thus produces a bronchodilatory effect. | ||
| - | ([[4u14]]). | + | <scene name='10/1013887/Cv/3'>M3 muscarinic acetylcholine receptor bound to the antagonist tiotropium</scene> ([[4u14]]). |
</StructureSection> | </StructureSection> | ||
== References == | == References == | ||
<references/> | <references/> | ||
Revision as of 13:38, 11 December 2023
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References
- ↑ 1.0 1.1 "Tiotropium Bromide Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Archived from the original on 14 October 2018. Retrieved 31 January 2019.
- ↑ British national formulary : BNF 76 (76th ed.). Pharmaceutical Press. 2018. pp. 247–248. ISBN 9780857113382.
- ↑ Kato M, Komamura K, Kitakaze M. Tiotropium, a novel muscarinic M3 receptor antagonist, improved symptoms of chronic obstructive pulmonary disease complicated by chronic heart failure. Circ J. 2006 Dec;70(12):1658-60. PMID:17127817 doi:10.1253/circj.70.1658
