8hpx
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of mouse LGI1 LRR domain in space group P65== | |
| - | + | <StructureSection load='8hpx' size='340' side='right'caption='[[8hpx]], [[Resolution|resolution]] 3.68Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8hpx]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8HPX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8HPX FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.68Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> |
| - | [[Category: Liu | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8hpx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8hpx OCA], [https://pdbe.org/8hpx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8hpx RCSB], [https://www.ebi.ac.uk/pdbsum/8hpx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8hpx ProSAT]</span></td></tr> |
| - | [[Category: Xu | + | </table> |
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/LGI1_MOUSE LGI1_MOUSE] Regulates voltage-gated potassium channels assembled from KCNA1, KCNA4 and KCNAB1. It slows down channel inactivation by precluding channel closure mediated by the KCNAB1 subunit. Ligand for ADAM22 that positively regulates synaptic transmission mediated by AMPA-type glutamate receptors. Plays a role in suppressing the production of MMP1/3 through the phosphatidylinositol 3-kinase/ERK pathway (By similarity). | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Mus musculus]] | ||
| + | [[Category: Liu H]] | ||
| + | [[Category: Xu F]] | ||
Current revision
Structure of mouse LGI1 LRR domain in space group P65
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