8hpw
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of mouse LGI1 LRR domain in space group P21== | |
| - | + | <StructureSection load='8hpw' size='340' side='right'caption='[[8hpw]], [[Resolution|resolution]] 2.39Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8hpw]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8HPW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8HPW FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.39Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> |
| - | [[Category: Liu | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8hpw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8hpw OCA], [https://pdbe.org/8hpw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8hpw RCSB], [https://www.ebi.ac.uk/pdbsum/8hpw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8hpw ProSAT]</span></td></tr> |
| - | [[Category: Xu | + | </table> |
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/LGI1_MOUSE LGI1_MOUSE] Regulates voltage-gated potassium channels assembled from KCNA1, KCNA4 and KCNAB1. It slows down channel inactivation by precluding channel closure mediated by the KCNAB1 subunit. Ligand for ADAM22 that positively regulates synaptic transmission mediated by AMPA-type glutamate receptors. Plays a role in suppressing the production of MMP1/3 through the phosphatidylinositol 3-kinase/ERK pathway (By similarity). | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Mus musculus]] | ||
| + | [[Category: Liu H]] | ||
| + | [[Category: Xu F]] | ||
Current revision
Crystal structure of mouse LGI1 LRR domain in space group P21
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