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| | <StructureSection load='1e5p' size='340' side='right'caption='[[1e5p]], [[Resolution|resolution]] 1.63Å' scene=''> | | <StructureSection load='1e5p' size='340' side='right'caption='[[1e5p]], [[Resolution|resolution]] 1.63Å' scene=''> |
| | == Structural highlights == | | == Structural highlights == |
| - | <table><tr><td colspan='2'>[[1e5p]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Golden_hamster Golden hamster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E5P OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1E5P FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[1e5p]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mesocricetus_auratus Mesocricetus auratus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E5P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1E5P FirstGlance]. <br> |
| - | </td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.63Å</td></tr> |
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MESOCRICETUS AURATUS APHRODISIN GENE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10036 Golden hamster])</td></tr> | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1e5p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1e5p OCA], [http://pdbe.org/1e5p PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1e5p RCSB], [http://www.ebi.ac.uk/pdbsum/1e5p PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1e5p ProSAT]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1e5p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1e5p OCA], [https://pdbe.org/1e5p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1e5p RCSB], [https://www.ebi.ac.uk/pdbsum/1e5p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1e5p ProSAT]</span></td></tr> |
| | </table> | | </table> |
| | == Function == | | == Function == |
| - | [[http://www.uniprot.org/uniprot/APHR_CRICR APHR_CRICR]] Acts as an aphrodisiac pheromone, reliably eliciting copulatory behavior from male hamster. | + | [https://www.uniprot.org/uniprot/APHR_CRICR APHR_CRICR] Acts as an aphrodisiac pheromone, reliably eliciting copulatory behavior from male hamster. |
| | == Evolutionary Conservation == | | == Evolutionary Conservation == |
| | [[Image:Consurf_key_small.gif|200px|right]] | | [[Image:Consurf_key_small.gif|200px|right]] |
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| | __TOC__ | | __TOC__ |
| | </StructureSection> | | </StructureSection> |
| - | [[Category: Golden hamster]] | |
| | [[Category: Large Structures]] | | [[Category: Large Structures]] |
| - | [[Category: Brown, K]] | + | [[Category: Mesocricetus auratus]] |
| - | [[Category: Cambillau, C]] | + | [[Category: Brown K]] |
| - | [[Category: Spinelli, S]] | + | [[Category: Cambillau C]] |
| - | [[Category: Tegoni, M]] | + | [[Category: Spinelli S]] |
| - | [[Category: Vincent, F]] | + | [[Category: Tegoni M]] |
| - | [[Category: Hamster]]
| + | [[Category: Vincent F]] |
| - | [[Category: Lipocalin]]
| + | |
| - | [[Category: Pheromone]]
| + | |
| Structural highlights
Function
APHR_CRICR Acts as an aphrodisiac pheromone, reliably eliciting copulatory behavior from male hamster.
Evolutionary Conservation
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
Publication Abstract from PubMed
We have solved the crystal structure of aphrodisin, a pheromonal protein inducing a copulatory behaviour in male hamster, using MAD methods with selenium, at 1.63 A resolution. The monomeric protein belongs to the lipocalin family, and possesses a disulfide bridge in a loop between strands 2 and 3. This disulfide bridge is characteristic of a family of lipocalins mainly identified in rodents, and is analogous to the fifth disulfide bridge of the long neurotoxins, such as alpha cobratoxin. An elongated electron density was found inside the buried cavity, which might represent a serendipitous ligand of unknown origin. The analysis of the water accessible surfaces of the side-chains bordering the cavity indicates that Phe76 may be the door for the natural ligand to access the cavity. This residue defines the entry of the cavity as belonging to the consensus for lipocalins. The face bearing Phe76 might also serve for the interaction with the receptor.
Crystal structure of aphrodisin, a sex pheromone from female hamster.,Vincent F, Lobel D, Brown K, Spinelli S, Grote P, Breer H, Cambillau C, Tegoni M J Mol Biol. 2001 Jan 19;305(3):459-69. PMID:11152604[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Vincent F, Lobel D, Brown K, Spinelli S, Grote P, Breer H, Cambillau C, Tegoni M. Crystal structure of aphrodisin, a sex pheromone from female hamster. J Mol Biol. 2001 Jan 19;305(3):459-69. PMID:11152604 doi:10.1006/jmbi.2000.4241
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