1e6e

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Current revision (11:53, 13 December 2023) (edit) (undo)
 
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<StructureSection load='1e6e' size='340' side='right'caption='[[1e6e]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
<StructureSection load='1e6e' size='340' side='right'caption='[[1e6e]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1e6e]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Bovin Bovin]. The October 2006 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Cytochrome p450'' by David S. Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2006_10 10.2210/rcsb_pdb/mom_2006_10]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E6E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1E6E FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1e6e]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. The October 2006 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Cytochrome p450'' by David S. Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2006_10 10.2210/rcsb_pdb/mom_2006_10]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E6E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1E6E FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=FES:FE2/S2+(INORGANIC)+CLUSTER'>FES</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1e1k|1e1k]], [[1e1l|1e1l]], [[1e1m|1e1m]], [[1e1n|1e1n]], [[1cjc|1cjc]], [[1cje|1cje]], [[1ayf|1ayf]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=FES:FE2/S2+(INORGANIC)+CLUSTER'>FES</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1e6e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1e6e OCA], [https://pdbe.org/1e6e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1e6e RCSB], [https://www.ebi.ac.uk/pdbsum/1e6e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1e6e ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1e6e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1e6e OCA], [https://pdbe.org/1e6e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1e6e RCSB], [https://www.ebi.ac.uk/pdbsum/1e6e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1e6e ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/ADRO_BOVIN ADRO_BOVIN]] Serves as the first electron transfer protein in all the mitochondrial P450 systems. Including cholesterol side chain cleavage in all steroidogenic tissues, steroid 11-beta hydroxylation in the adrenal cortex, 25-OH-vitamin D3-24 hydroxylation in the kidney, and sterol C-27 hydroxylation in the liver. [[https://www.uniprot.org/uniprot/ADX_BOVIN ADX_BOVIN]] Essential for the synthesis of various steroid hormones, participates in the reduction of mitochondrial cytochrome P450 for steroidogenesis. Transfers electrons from adrenodoxin reductase to cytochrome P450 cholesterol side-chain cleavage enzyme. reductase to the cholesterol side chain cleavage cytochrome P450 (By similarity).
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[https://www.uniprot.org/uniprot/ADRO_BOVIN ADRO_BOVIN] Serves as the first electron transfer protein in all the mitochondrial P450 systems. Including cholesterol side chain cleavage in all steroidogenic tissues, steroid 11-beta hydroxylation in the adrenal cortex, 25-OH-vitamin D3-24 hydroxylation in the kidney, and sterol C-27 hydroxylation in the liver.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Bovin]]
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[[Category: Bos taurus]]
[[Category: Cytochrome p450]]
[[Category: Cytochrome p450]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: RCSB PDB Molecule of the Month]]
[[Category: RCSB PDB Molecule of the Month]]
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[[Category: Bourenkov, G]]
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[[Category: Bourenkov G]]
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[[Category: Heinemann, U]]
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[[Category: Heinemann U]]
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[[Category: Lapko, A]]
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[[Category: Lapko A]]
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[[Category: Mueller, J J]]
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[[Category: Mueller JJ]]
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[[Category: Ruckpaul, K]]
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[[Category: Ruckpaul K]]
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[[Category: Adrenodoxin]]
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[[Category: Complex]]
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[[Category: Electron transferase]]
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[[Category: Electron transport]]
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[[Category: Flavoenzyme]]
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[[Category: Oxidoreductase]]
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Current revision

ADRENODOXIN REDUCTASE/ADRENODOXIN COMPLEX OF MITOCHONDRIAL P450 SYSTEMS

PDB ID 1e6e

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