1e8d

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Current revision (11:56, 13 December 2023) (edit) (undo)
 
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<StructureSection load='1e8d' size='340' side='right'caption='[[1e8d]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
<StructureSection load='1e8d' size='340' side='right'caption='[[1e8d]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1e8d]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Cassava Cassava]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E8D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1E8D FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1e8d]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Manihot_esculenta Manihot esculenta]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E8D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1E8D FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CNH:2-HYDROXY-2-METHYLPROPANENITRILE'>CNH</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1dwo|1dwo]], [[1dwp|1dwp]], [[1dwq|1dwq]], [[1e89|1e89]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CNH:2-HYDROXY-2-METHYLPROPANENITRILE'>CNH</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Trans-epoxysuccinate_hydrolase Trans-epoxysuccinate hydrolase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.3.2.4 3.3.2.4] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1e8d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1e8d OCA], [https://pdbe.org/1e8d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1e8d RCSB], [https://www.ebi.ac.uk/pdbsum/1e8d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1e8d ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1e8d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1e8d OCA], [https://pdbe.org/1e8d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1e8d RCSB], [https://www.ebi.ac.uk/pdbsum/1e8d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1e8d ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/HNL_MANES HNL_MANES] Involved in cyanogenesis, the release of HCN from injured tissues. Decomposes a varieties of (R) or (S) cyanohydrins into HCN and the corresponding aldehydes and ketones. The natural substrate of this enzyme is (S)-acetone cyanohydrin.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Cassava]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Trans-epoxysuccinate hydrolase]]
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[[Category: Manihot esculenta]]
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[[Category: Effenberger, F]]
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[[Category: Effenberger F]]
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[[Category: Foerster, S]]
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[[Category: Foerster S]]
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[[Category: Lauble, H]]
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[[Category: Lauble H]]
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[[Category: Miehlich, B]]
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[[Category: Miehlich B]]
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[[Category: Wajant, H]]
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[[Category: Wajant H]]
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[[Category: Acetone cyanohydrin complex]]
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[[Category: Active site mutant]]
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[[Category: Hydroxynitrile lyase]]
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[[Category: Lyase]]
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Current revision

MECHANISTIC ASPECTS OF CYANOGENESIS FROM ACTIVE SITE MUTANT SER80ALA OF HYDROXYNITRILE LYASE FROM MANIHOT ESCULENTA IN COMPLEX WITH ACETONE CYANOHYDRIN

PDB ID 1e8d

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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