1out

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[[Image:1out.jpg|left|200px]]
[[Image:1out.jpg|left|200px]]
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{{Structure
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The line below this paragraph, containing "STRUCTURE_1out", creates the "Structure Box" on the page.
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|LIGAND= <scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>
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{{STRUCTURE_1out| PDB=1out | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1out FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1out OCA], [http://www.ebi.ac.uk/pdbsum/1out PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1out RCSB]</span>
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'''TROUT HEMOGLOBIN I'''
'''TROUT HEMOGLOBIN I'''
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[[Category: Tame, J.]]
[[Category: Tame, J.]]
[[Category: Wilson, J.]]
[[Category: Wilson, J.]]
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[[Category: erythrocyte]]
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[[Category: Erythrocyte]]
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[[Category: heme]]
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[[Category: Heme]]
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[[Category: oxygen transport]]
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[[Category: Oxygen transport]]
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[[Category: respiratory protein]]
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[[Category: Respiratory protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 04:18:22 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:50:37 2008''
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Revision as of 01:18, 3 May 2008

Image:1out.jpg

Template:STRUCTURE 1out

TROUT HEMOGLOBIN I


Overview

We have determined the X-ray crystallographic structure of trout Hb I in both the deoxy and carbonmonoxy forms to resolution limits of 2.3 angstroms and 2.5 angstroms, respectively. The overall fold of the molecule is highly similar to that of human HbA despite the low level of sequence identity between these proteins. Trout Hb I is unusual in displaying almost no pH dependence of oxygen binding affinity, and (at most) very weak interactions with heterotropic effector ligands such as organic phosphates. Comparison of the two quaternary states of the protein indicates how such effects are minimised and how the low-affinity T state of the protein is stabilised in the absence of heterotropic interactions.

About this Structure

1OUT is a Protein complex structure of sequences from Oncorhynchus mykiss. Full crystallographic information is available from OCA.

Reference

The crystal structures of trout Hb I in the deoxy and carbonmonoxy forms., Tame JR, Wilson JC, Weber RE, J Mol Biol. 1996 Jun 21;259(4):749-60. PMID:8683580 Page seeded by OCA on Sat May 3 04:18:22 2008

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OCA

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