1ov3

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[[Image:1ov3.gif|left|200px]]
[[Image:1ov3.gif|left|200px]]
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{{Structure
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|GENE= NCF1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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{{STRUCTURE_1ov3| PDB=1ov3 | SCENE= }}
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|RELATEDENTRY=[[1ng2|1NG2]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ov3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ov3 OCA], [http://www.ebi.ac.uk/pdbsum/1ov3 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1ov3 RCSB]</span>
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'''Structure of the p22phox-p47phox complex'''
'''Structure of the p22phox-p47phox complex'''
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[[Category: Rittinger, K.]]
[[Category: Rittinger, K.]]
[[Category: Smerdon, S J.]]
[[Category: Smerdon, S J.]]
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[[Category: complex]]
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[[Category: Complex]]
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[[Category: nadph oxidase]]
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[[Category: Nadph oxidase]]
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[[Category: p22phox]]
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[[Category: P22phox]]
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[[Category: p47phox]]
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[[Category: P47phox]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 04:18:53 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:50:43 2008''
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Revision as of 01:18, 3 May 2008

Image:1ov3.gif

Template:STRUCTURE 1ov3

Structure of the p22phox-p47phox complex


Contents

Overview

The multi-subunit NADPH oxidase complex plays a crucial role in host defense against microbial infection through the production of reactive oxygen species. Activation of the NADPH oxidase requires the targeting of a cytoplasmic p40-p47-p67(phox) complex to the membrane bound heterodimeric p22-gp91(phox) flavocytochrome. This interaction is prevented in the resting state due to an auto-inhibited conformation of p47(phox). The X-ray structure of the auto-inhibited form of p47(phox) reveals that tandem SH3 domains function together to maintain the cytoplasmic complex in an inactive form. Further structural and biochemical data show that phosphorylation of p47(phox) activates a molecular switch that relieves the inhibitory intramolecular interaction. This permits p47(phox) to interact with the cytoplasmic tail of p22(phox) and initiate formation of the active, membrane bound enzyme complex.

Disease

Known disease associated with this structure: Chronic granulomatous disease due to deficiency of NCF-1 OMIM:[608512]

About this Structure

1OV3 is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Molecular basis of phosphorylation-induced activation of the NADPH oxidase., Groemping Y, Lapouge K, Smerdon SJ, Rittinger K, Cell. 2003 May 2;113(3):343-55. PMID:12732142 Page seeded by OCA on Sat May 3 04:18:53 2008

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