1ovl

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[[Image:1ovl.gif|left|200px]]
[[Image:1ovl.gif|left|200px]]
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{{Structure
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|PDB= 1ovl |SIZE=350|CAPTION= <scene name='initialview01'>1ovl</scene>, resolution 2.2&Aring;
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The line below this paragraph, containing "STRUCTURE_1ovl", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=BR:BROMIDE+ION'>BR</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>
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|ACTIVITY=
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|GENE= NR4A2 OR NURR1 OR TINUR OR NOT ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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{{STRUCTURE_1ovl| PDB=1ovl | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ovl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ovl OCA], [http://www.ebi.ac.uk/pdbsum/1ovl PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1ovl RCSB]</span>
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'''Crystal Structure of Nurr1 LBD'''
'''Crystal Structure of Nurr1 LBD'''
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[[Category: Walker, N.]]
[[Category: Walker, N.]]
[[Category: Wang, Z.]]
[[Category: Wang, Z.]]
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[[Category: lbd]]
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[[Category: Lbd]]
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[[Category: nuur1]]
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[[Category: Nuur1]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 04:19:50 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:50:57 2008''
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Revision as of 01:19, 3 May 2008

Image:1ovl.gif

Template:STRUCTURE 1ovl

Crystal Structure of Nurr1 LBD


Overview

Members of the nuclear receptor (NR) superfamily of transcription factors modulate gene transcription in response to small lipophilic molecules. Transcriptional activity is regulated by ligands binding to the carboxy-terminal ligand-binding domains (LBDs) of cognate NRs. A subgroup of NRs referred to as 'orphan receptors' lack identified ligands, however, raising issues about the function of their LBDs. Here we report the crystal structure of the LBD of the orphan receptor Nurr1 at 2.2 A resolution. The Nurr1 LBD adopts a canonical protein fold resembling that of agonist-bound, transcriptionally active LBDs in NRs, but the structure has two distinctive features. First, the Nurr1 LBD contains no cavity as a result of the tight packing of side chains from several bulky hydrophobic residues in the region normally occupied by ligands. Second, Nurr1 lacks a 'classical' binding site for coactivators. Despite these differences, the Nurr1 LBD can be regulated in mammalian cells. Notably, transcriptional activity is correlated with the Nurr1 LBD adopting a more stable conformation. Our findings highlight a unique structural class of NRs and define a model for ligand-independent NR function.

About this Structure

1OVL is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure and function of Nurr1 identifies a class of ligand-independent nuclear receptors., Wang Z, Benoit G, Liu J, Prasad S, Aarnisalo P, Liu X, Xu H, Walker NP, Perlmann T, Nature. 2003 May 29;423(6939):555-60. PMID:12774125 Page seeded by OCA on Sat May 3 04:19:50 2008

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