1ow3

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[[Image:1ow3.jpg|left|200px]]
[[Image:1ow3.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 1ow3 |SIZE=350|CAPTION= <scene name='initialview01'>1ow3</scene>, resolution 1.80&Aring;
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The line below this paragraph, containing "STRUCTURE_1ow3", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=GDP:GUANOSINE-5&#39;-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MGF:TRIFLUOROMAGNESATE'>MGF</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE= RHOGAP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), RHOA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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|DOMAIN=
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{{STRUCTURE_1ow3| PDB=1ow3 | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ow3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ow3 OCA], [http://www.ebi.ac.uk/pdbsum/1ow3 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1ow3 RCSB]</span>
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}}
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'''Crystal Structure of RhoA.GDP.MgF3-in Complex with RhoGAP'''
'''Crystal Structure of RhoA.GDP.MgF3-in Complex with RhoGAP'''
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[[Category: Rittinger, K.]]
[[Category: Rittinger, K.]]
[[Category: Smerdon, S J.]]
[[Category: Smerdon, S J.]]
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[[Category: complex]]
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[[Category: Complex]]
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[[Category: gap]]
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[[Category: Gap]]
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[[Category: gtpase]]
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[[Category: Gtpase]]
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[[Category: transition state]]
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[[Category: Transition state]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 04:20:50 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:51:12 2008''
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Revision as of 01:20, 3 May 2008

Image:1ow3.jpg

Template:STRUCTURE 1ow3

Crystal Structure of RhoA.GDP.MgF3-in Complex with RhoGAP


Overview

The formation of complexes between small G proteins and certain of their effectors can be facilitated by aluminum fluorides. Solution studies suggest that magnesium may be able to replace aluminum in such complexes. We have determined the crystal structure of RhoA.GDP bound to RhoGAP in the presence of Mg(2+) and F(-) but without Al(3+). The metallofluoride adopts a trigonal planar arrangement instead of the square planar structure of AlF(4)(-). We have confirmed that these crystals contain magnesium and not aluminum by proton-induced X-ray emission spectroscopy. The structure adopted by GDP.MgF(-) possesses the stereochemistry and approximate charge expected for the transition state. We suggest that MgF3(-) may be the reagent of choice for studying phosphoryl transfer reactions.

About this Structure

1OW3 is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

MgF(3)(-) as a transition state analog of phosphoryl transfer., Graham DL, Lowe PN, Grime GW, Marsh M, Rittinger K, Smerdon SJ, Gamblin SJ, Eccleston JF, Chem Biol. 2002 Mar;9(3):375-81. PMID:11927263 Page seeded by OCA on Sat May 3 04:20:50 2008

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