2c15
From Proteopedia
(Difference between revisions)
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<StructureSection load='2c15' size='340' side='right'caption='[[2c15]], [[Resolution|resolution]] 1.48Å' scene=''> | <StructureSection load='2c15' size='340' side='right'caption='[[2c15]], [[Resolution|resolution]] 1.48Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2c15]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[2c15]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C15 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2C15 FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.48Å</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LET:(Z)-N^6-{3-CARBOXY-1-[(4-CARBOXY-2-OXOBUTOXY)METHYL]PROPYLIDENE}-L-LYSINE'>LET</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> |
| - | + | ||
| - | + | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2c15 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c15 OCA], [https://pdbe.org/2c15 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2c15 RCSB], [https://www.ebi.ac.uk/pdbsum/2c15 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2c15 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2c15 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c15 OCA], [https://pdbe.org/2c15 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2c15 RCSB], [https://www.ebi.ac.uk/pdbsum/2c15 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2c15 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/HEM2_PSEAE HEM2_PSEAE] Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen (By similarity). | |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Porphobilinogen synthase]] | ||
| - | [[Category: Frankenberg-Dinkel, N]] | ||
| - | [[Category: Frere, F]] | ||
| - | [[Category: Gacond, S]] | ||
| - | [[Category: Heinz, D W]] | ||
| - | [[Category: Neier, R]] | ||
| - | [[Category: Nentwich, M]] | ||
| - | [[Category: Enzyme mechanism]] | ||
| - | [[Category: Lyase]] | ||
| - | [[Category: Magnesium]] | ||
| - | [[Category: Metal-binding]] | ||
| - | [[Category: Metalloenzyme]] | ||
| - | [[Category: Porphyrin biosynthesis]] | ||
[[Category: Pseudomonas aeruginosa]] | [[Category: Pseudomonas aeruginosa]] | ||
| + | [[Category: Frankenberg-Dinkel N]] | ||
| + | [[Category: Frere F]] | ||
| + | [[Category: Gacond S]] | ||
| + | [[Category: Heinz DW]] | ||
| + | [[Category: Neier R]] | ||
| + | [[Category: Nentwich M]] | ||
Revision as of 14:01, 13 December 2023
5-(4-Carboxy-2-oxo-butoxy)-4-oxo-pentanoic acid acid bound to Porphobilinogen synthase from Pseudomonas aeruginosa
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