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2cbx
From Proteopedia
(Difference between revisions)
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<StructureSection load='2cbx' size='340' side='right'caption='[[2cbx]], [[Resolution|resolution]] 2.00Å' scene=''> | <StructureSection load='2cbx' size='340' side='right'caption='[[2cbx]], [[Resolution|resolution]] 2.00Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2cbx]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[2cbx]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_cattleya Streptomyces cattleya]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CBX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CBX FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2Å</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CC5:BETA-D-ERYTHROFURANOSYL-ADENOSINE'>CC5</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr> |
| - | + | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cbx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cbx OCA], [https://pdbe.org/2cbx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cbx RCSB], [https://www.ebi.ac.uk/pdbsum/2cbx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cbx ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cbx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cbx OCA], [https://pdbe.org/2cbx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cbx RCSB], [https://www.ebi.ac.uk/pdbsum/2cbx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cbx ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/FLA_STRCT FLA_STRCT] Involved in the biosynthesis of fluorometabolites. Catalyzes the formation of a C-F bond by combining S-adenosyl-L-methionine (SAM) and fluoride to generate 5'-fluoro-5'-deoxyadenosine (5'-FDA) and L-methionine. It can also use 2'-deoxyadenosine in place of adenosine as substrate.<ref>PMID:12860396</ref> <ref>PMID:14765200</ref> <ref>PMID:16370017</ref> <ref>PMID:16604208</ref> <ref>PMID:16720268</ref> <ref>PMID:17985882</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: Streptomyces cattleya kahan et al. 1979]] | ||
| - | [[Category: Adenosyl-fluoride synthase]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Cadicamo, C D]] | ||
| - | [[Category: Deng, H]] | ||
| - | [[Category: Hagan, D O]] | ||
| - | [[Category: McEwan, A R]] | ||
| - | [[Category: McGlinchey, R P]] | ||
| - | [[Category: Naismith, J H]] | ||
| - | [[Category: Robinson, D R]] | ||
| - | [[Category: Spencer, J]] | ||
| - | [[Category: 5'-fluorodeoxyadenosine synthase]] | ||
| - | [[Category: Aza]] | ||
| - | [[Category: Fla]] | ||
| - | [[Category: Fluorinase]] | ||
| - | [[Category: Inhibitor]] | ||
| - | [[Category: Sam analogue]] | ||
[[Category: Streptomyces cattleya]] | [[Category: Streptomyces cattleya]] | ||
| - | [[Category: | + | [[Category: Cadicamo CD]] |
| + | [[Category: Deng H]] | ||
| + | [[Category: McEwan AR]] | ||
| + | [[Category: McGlinchey RP]] | ||
| + | [[Category: Naismith JH]] | ||
| + | [[Category: O'Hagan D]] | ||
| + | [[Category: Robinson DR]] | ||
| + | [[Category: Spencer J]] | ||
Current revision
X-ray crystal structure of 5'-fluorodeoxyadenosine synthase from Streptomyces cattleya complexed with beta-D-erythrofuranosyl- adenosine
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