2clp
From Proteopedia
(Difference between revisions)
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<StructureSection load='2clp' size='340' side='right'caption='[[2clp]], [[Resolution|resolution]] 3.00Å' scene=''> | <StructureSection load='2clp' size='340' side='right'caption='[[2clp]], [[Resolution|resolution]] 3.00Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2clp]] is a 11 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[2clp]] is a 11 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CLP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CLP FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3Å</td></tr> |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2clp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2clp OCA], [https://pdbe.org/2clp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2clp RCSB], [https://www.ebi.ac.uk/pdbsum/2clp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2clp ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2clp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2clp OCA], [https://pdbe.org/2clp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2clp RCSB], [https://www.ebi.ac.uk/pdbsum/2clp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2clp ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/ARK73_HUMAN ARK73_HUMAN] Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen.<ref>PMID:18416522</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2clp ConSurf]. | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2clp ConSurf]. | ||
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Arrowsmith | + | [[Category: Arrowsmith C]] |
| - | [[Category: Debreczeni | + | [[Category: Debreczeni JE]] |
| - | + | [[Category: Edwards A]] | |
| - | [[Category: Edwards | + | [[Category: Gileadi O]] |
| - | [[Category: Gileadi | + | [[Category: Guo K]] |
| - | [[Category: Guo | + | [[Category: Johansson C]] |
| - | [[Category: Johansson | + | [[Category: Kavanagh K]] |
| - | [[Category: Kavanagh | + | [[Category: Marsden BD]] |
| - | [[Category: Marsden | + | [[Category: Oppermann U]] |
| - | [[Category: Oppermann | + | [[Category: Papagrigoriou E]] |
| - | [[Category: Papagrigoriou | + | [[Category: Smee C]] |
| - | [[Category: Smee | + | [[Category: Sundstrom M]] |
| - | [[Category: Sundstrom | + | [[Category: Turnbull A]] |
| - | [[Category: Turnbull | + | [[Category: Weigelt J]] |
| - | [[Category: Weigelt | + | [[Category: Von Delft F]] |
| - | [[Category: | + | |
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Current revision
Crystal structure of human aflatoxin B1 aldehyde reductase member 3
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Categories: Homo sapiens | Large Structures | Arrowsmith C | Debreczeni JE | Edwards A | Gileadi O | Guo K | Johansson C | Kavanagh K | Marsden BD | Oppermann U | Papagrigoriou E | Smee C | Sundstrom M | Turnbull A | Weigelt J | Von Delft F
