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2co0

From Proteopedia

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Current revision (14:24, 13 December 2023) (edit) (undo)
 
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<StructureSection load='2co0' size='340' side='right'caption='[[2co0]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
<StructureSection load='2co0' size='340' side='right'caption='[[2co0]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2co0]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CO0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CO0 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2co0]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CO0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CO0 FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2cnx|2cnx]], [[2gnq|2gnq]]</div></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.25&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2co0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2co0 OCA], [https://pdbe.org/2co0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2co0 RCSB], [https://www.ebi.ac.uk/pdbsum/2co0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2co0 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2co0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2co0 OCA], [https://pdbe.org/2co0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2co0 RCSB], [https://www.ebi.ac.uk/pdbsum/2co0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2co0 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/WDR5_HUMAN WDR5_HUMAN]] Contributes to histone modification. May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4'. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. May regulate osteoblasts differentiation.<ref>PMID:19556245</ref> <ref>PMID:19103755</ref> <ref>PMID:20018852</ref> <ref>PMID:16600877</ref> <ref>PMID:16829960</ref>
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[https://www.uniprot.org/uniprot/H31_HUMAN H31_HUMAN]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Allis, C D]]
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[[Category: Allis CD]]
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[[Category: Graybosch, D M]]
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[[Category: Graybosch DM]]
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[[Category: Li, H]]
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[[Category: Li H]]
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[[Category: Patel, D J]]
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[[Category: Patel DJ]]
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[[Category: Ruthenburg, A J]]
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[[Category: Ruthenburg AJ]]
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[[Category: Verdine, G L]]
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[[Category: Verdine GL]]
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[[Category: Wang, W]]
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[[Category: Wang W]]
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[[Category: Histone presenter]]
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[[Category: Hox gene activation]]
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[[Category: Leukemia]]
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[[Category: Lysine methylation]]
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[[Category: Mll1]]
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[[Category: Transcription]]
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[[Category: Transcription activation]]
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Current revision

WDR5 and unmodified Histone H3 complex at 2.25 angstrom

PDB ID 2co0

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