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2ix5

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Current revision (14:28, 13 December 2023) (edit) (undo)
 
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<StructureSection load='2ix5' size='340' side='right'caption='[[2ix5]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
<StructureSection load='2ix5' size='340' side='right'caption='[[2ix5]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2ix5]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Arath Arath]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IX5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2IX5 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2ix5]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IX5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2IX5 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CAA:ACETOACETYL-COENZYME+A'>CAA</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1is2|1is2]], [[1w07|1w07]], [[2ddh|2ddh]], [[2fon|2fon]], [[2ix6|2ix6]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CAA:ACETOACETYL-COENZYME+A'>CAA</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Acyl-CoA_oxidase Acyl-CoA oxidase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.3.6 1.3.3.6] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ix5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ix5 OCA], [https://pdbe.org/2ix5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ix5 RCSB], [https://www.ebi.ac.uk/pdbsum/2ix5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ix5 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ix5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ix5 OCA], [https://pdbe.org/2ix5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ix5 RCSB], [https://www.ebi.ac.uk/pdbsum/2ix5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ix5 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/ACOX4_ARATH ACOX4_ARATH]] Catalyzes the desaturation of short-chain acyl-CoAs to 2-trans-enoyl-CoAs. Active on butyryl-CoA (C4), hexanoyl-CoA (C6), and octanoyl-CoA (C8). Has no activity as acyl-CoA dehydrogenase or on crotonyl-CoA (an unsaturated C4:1 carbocyclic ester) or glutaryl-CoA (a dicarboxylic ester).
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[https://www.uniprot.org/uniprot/ACOX4_ARATH ACOX4_ARATH] Catalyzes the desaturation of short-chain acyl-CoAs to 2-trans-enoyl-CoAs. Active on butyryl-CoA (C4), hexanoyl-CoA (C6), and octanoyl-CoA (C8). Has no activity as acyl-CoA dehydrogenase or on crotonyl-CoA (an unsaturated C4:1 carbocyclic ester) or glutaryl-CoA (a dicarboxylic ester).
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Acyl-CoA oxidase]]
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[[Category: Arabidopsis thaliana]]
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[[Category: Arath]]
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[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Arent, S]]
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[[Category: Arent S]]
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[[Category: Henriksen, A]]
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[[Category: Henriksen A]]
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[[Category: Mackenzie, J]]
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[[Category: Mackenzie J]]
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[[Category: Pedersen, L]]
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[[Category: Pedersen L]]
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[[Category: Acx4]]
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[[Category: Acyl-coa oxidase]]
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[[Category: Beta-oxidation]]
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[[Category: Electron transfer]]
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[[Category: Fad]]
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[[Category: Fatty acid metabolism]]
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[[Category: Flavin]]
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[[Category: Flavoprotein]]
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[[Category: Glyoxysome]]
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[[Category: Lipid metabolism]]
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[[Category: Oxidoreductase]]
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[[Category: Peroxisome]]
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Current revision

Short chain specific acyl-CoA oxidase from Arabidopsis thaliana, ACX4 in complex with acetoacetyl-CoA

PDB ID 2ix5

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OCA

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