2iyl

From Proteopedia

(Difference between revisions)

Current revision

Structure of an FtsY:GDP complex

Structural highlights

2iyl is a 1 chain structure with sequence from Thermus aquaticus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 2.1Å
Ligands:	,
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

FTSY_THEAQ Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) (By similarity).

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

FtsY and Ffh are structurally similar prokaryotic Signal Recognition Particle GTPases that play an essential role in the Signal Recognition Particle (SRP)-mediated cotranslational targeting of proteins to the membrane. The two GTPases assemble in a GTP-dependent manner to form a heterodimeric SRP targeting complex. We report here the 2.1 A X-ray structure of FtsY from T. aquaticus bound to GDP. The structure of the monomeric protein reveals, unexpectedly, canonical binding interactions for GDP. A comparison of the structures of the monomeric and complexed FtsY NG GTPase domain suggests that it undergoes a conformational change similar to that of Ffh NG during the assembly of the symmetric heterodimeric complex. However, in contrast to Ffh, in which the C-terminal helix shifts independently of the other subdomains, the C-terminal helix and N domain of T. aquaticus FtsY together behave as a rigid body during assembly, suggesting distinct mechanisms by which the interactions of the NG domain "module" are regulated in the context of the two SRP GTPases.

X-ray structure of the T. aquaticus FtsY:GDP complex suggests functional roles for the C-terminal helix of the SRP GTPases.,Gawronski-Salerno J, Coon JS 5th, Focia PJ, Freymann DM Proteins. 2007 Mar 1;66(4):984-95. PMID:17186523^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Gawronski-Salerno J, Coon JS 5th, Focia PJ, Freymann DM. X-ray structure of the T. aquaticus FtsY:GDP complex suggests functional roles for the C-terminal helix of the SRP GTPases. Proteins. 2007 Mar 1;66(4):984-95. PMID:17186523 doi:10.1002/prot.21200

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 Publication Abstract from PubMed
5 See Also
6 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2iyl"

Categories: Large Structures | Thermus aquaticus | Focia PJ | Freymann DM

@@ Line 3: / Line 3: @@
 <StructureSection load='2iyl' size='340' side='right'caption='[[2iyl]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[2iyl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_25104 Atcc 25104]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IYL OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2IYL FirstGlance]. <br>
+<table><tr><td colspan='2'>[[2iyl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_aquaticus Thermus aquaticus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IYL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2IYL FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
-<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1okk|1okk]], [[1rj9|1rj9]], [[1fts|1fts]], [[1zu4|1zu4]], [[1vma|1vma]], [[1ng1|1ng1]], [[2cnw|2cnw]]</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2iyl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2iyl OCA], [http://pdbe.org/2iyl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2iyl RCSB], [http://www.ebi.ac.uk/pdbsum/2iyl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2iyl ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2iyl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2iyl OCA], [https://pdbe.org/2iyl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2iyl RCSB], [https://www.ebi.ac.uk/pdbsum/2iyl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2iyl ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/FTSY_THEAQ FTSY_THEAQ]] Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) (By similarity).
+[https://www.uniprot.org/uniprot/FTSY_THEAQ FTSY_THEAQ] Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) (By similarity).
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
@@ Line 31: / Line 31: @@
 ==See Also==
-*[[Signal recognition particle receptor|Signal recognition particle receptor]]
+*[[Signal recognition particle receptor 3D structures|Signal recognition particle receptor 3D structures]]
 == References ==
 <references/>
 __TOC__
 </StructureSection>
-[[Category: Atcc 25104]]
 [[Category: Large Structures]]
-[[Category: Focia, P J]]
+[[Category: Thermus aquaticus]]
-[[Category: Freymann, D M]]
+[[Category: Focia PJ]]
-[[Category: Cell cycle]]
+[[Category: Freymann DM]]
-[[Category: Cell division]]
-[[Category: Ffh]]
-[[Category: Ftsy]]
-[[Category: Gdp]]
-[[Category: Gtp-binding]]
-[[Category: Gtpase]]
-[[Category: Inner membrane]]
-[[Category: Membrane]]
-[[Category: Nucleotide-binding]]
-[[Category: Ribonucleoprotein]]
-[[Category: Rna-binding]]
-[[Category: Signal recognition particle]]
-[[Category: Srp]]

2iyl

From Proteopedia

Current revision

Structure of an FtsY:GDP complex

Structural highlights

Function

Evolutionary Conservation

Publication Abstract from PubMed

See Also

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

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