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2iyy

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Current revision (14:30, 13 December 2023) (edit) (undo)
 
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<StructureSection load='2iyy' size='340' side='right'caption='[[2iyy]], [[Resolution|resolution]] 1.62&Aring;' scene=''>
<StructureSection load='2iyy' size='340' side='right'caption='[[2iyy]], [[Resolution|resolution]] 1.62&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2iyy]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Myctu Myctu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IYY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2IYY FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2iyy]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IYY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2IYY FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=S3P:SHIKIMATE-3-PHOSPHATE'>S3P</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.62&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1l4u|1l4u]], [[1l4y|1l4y]], [[1u8a|1u8a]], [[1zyu|1zyu]], [[2g1j|2g1j]], [[2g1k|2g1k]], [[2iyq|2iyq]], [[2iyr|2iyr]], [[2iys|2iys]], [[2iyt|2iyt]], [[2iyu|2iyu]], [[2iyv|2iyv]], [[2iyw|2iyw]], [[2iyx|2iyx]], [[2iyz|2iyz]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=S3P:SHIKIMATE-3-PHOSPHATE'>S3P</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Shikimate_kinase Shikimate kinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.71 2.7.1.71] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2iyy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2iyy OCA], [https://pdbe.org/2iyy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2iyy RCSB], [https://www.ebi.ac.uk/pdbsum/2iyy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2iyy ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2iyy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2iyy OCA], [https://pdbe.org/2iyy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2iyy RCSB], [https://www.ebi.ac.uk/pdbsum/2iyy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2iyy ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/AROK_MYCTU AROK_MYCTU]] Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.<ref>PMID:11483005</ref> <ref>PMID:17020768</ref>
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[https://www.uniprot.org/uniprot/AROK_MYCTU AROK_MYCTU] Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.<ref>PMID:11483005</ref> <ref>PMID:17020768</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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==See Also==
==See Also==
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*[[Shikimate kinase|Shikimate kinase]]
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*[[Shikimate kinase 3D structures|Shikimate kinase 3D structures]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Myctu]]
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[[Category: Mycobacterium tuberculosis H37Rv]]
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[[Category: Shikimate kinase]]
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[[Category: Bartunik HD]]
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[[Category: Bartunik, H D]]
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[[Category: Bourenkov GP]]
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[[Category: Bourenkov, G P]]
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[[Category: Hartmann MD]]
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[[Category: Hartmann, M D]]
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[[Category: Oberschall A]]
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[[Category: Oberschall, A]]
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[[Category: Strizhov N]]
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[[Category: Strizhov, N]]
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[[Category: Amino-acid biosynthesis]]
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[[Category: Aromatic amino acid biosynthesis]]
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[[Category: Atp-binding]]
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[[Category: Kinase]]
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[[Category: Magnesium]]
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[[Category: Metal-binding]]
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[[Category: Nucleotide-binding]]
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[[Category: P-loop kinase]]
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[[Category: Shikimate pathway]]
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[[Category: Transferase]]
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Current revision

Shikimate kinase from Mycobacterium tuberculosis in complex with shikimate-3-phosphate and SO4

PDB ID 2iyy

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Proteopedia Page Contributors and Editors (what is this?)

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