2izr

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Current revision (14:30, 13 December 2023) (edit) (undo)
 
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<StructureSection load='2izr' size='340' side='right'caption='[[2izr]], [[Resolution|resolution]] 1.30&Aring;' scene=''>
<StructureSection load='2izr' size='340' side='right'caption='[[2izr]], [[Resolution|resolution]] 1.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2izr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IZR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2IZR FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2izr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IZR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2IZR FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BRK:{(2Z)-4-AMINO-2-[(4-METHOXYPHENYL)IMINO]-2,3-DIHYDRO-1,3-THIAZOL-5-YL}(4-METHOXYPHENYL)METHANONE'>BRK</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PGO:S-1,2-PROPANEDIOL'>PGO</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.3&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2chl|2chl]], [[2izs|2izs]], [[2izt|2izt]], [[2izu|2izu]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BRK:{(2Z)-4-AMINO-2-[(4-METHOXYPHENYL)IMINO]-2,3-DIHYDRO-1,3-THIAZOL-5-YL}(4-METHOXYPHENYL)METHANONE'>BRK</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PGO:S-1,2-PROPANEDIOL'>PGO</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2izr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2izr OCA], [https://pdbe.org/2izr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2izr RCSB], [https://www.ebi.ac.uk/pdbsum/2izr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2izr ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2izr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2izr OCA], [https://pdbe.org/2izr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2izr RCSB], [https://www.ebi.ac.uk/pdbsum/2izr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2izr ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/KC1G3_HUMAN KC1G3_HUMAN] Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Regulates fast synaptic transmission mediated by glutamate (By similarity).
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Non-specific serine/threonine protein kinase]]
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[[Category: Arrowsmith C]]
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[[Category: Arrowsmith, C]]
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[[Category: Bunkoczi G]]
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[[Category: Bunkoczi, G]]
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[[Category: Das S]]
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[[Category: Das, S]]
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[[Category: Debreczeni JE]]
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[[Category: Debreczeni, J E]]
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[[Category: Edwards A]]
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[[Category: Delft, F von]]
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[[Category: Fedorov O]]
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[[Category: Edwards, A]]
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[[Category: Gileadi O]]
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[[Category: Fedorov, O]]
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[[Category: Knapp S]]
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[[Category: Gileadi, O]]
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[[Category: Rellos P]]
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[[Category: Knapp, S]]
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[[Category: Salah E]]
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[[Category: Rellos, P]]
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[[Category: Savitsky P]]
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[[Category: Salah, E]]
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[[Category: Sundstrom M]]
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[[Category: Savitsky, P]]
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[[Category: Weigelt J]]
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[[Category: Sundstrom, M]]
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[[Category: Von Delft F]]
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[[Category: Weigelt, J]]
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[[Category: Alternative splicing]]
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[[Category: Atp-binding]]
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[[Category: Kinase]]
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[[Category: Nucleotide-binding]]
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[[Category: Phosphorylation]]
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[[Category: Serine/threonine kinase]]
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[[Category: Serine/threonine-protein kinase]]
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[[Category: Transferase]]
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[[Category: Wnt signaling pathway]]
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Current revision

Structure of casein kinase gamma 3 in complex with inhibitor

PDB ID 2izr

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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