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1oxa

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[[Image:1oxa.jpg|left|200px]]
[[Image:1oxa.jpg|left|200px]]
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{{Structure
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The line below this paragraph, containing "STRUCTURE_1oxa", creates the "Structure Box" on the page.
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|LIGAND= <scene name='pdbligand=DEB:6-DEOXYERYTHRONOLIDE+B'>DEB</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>
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{{STRUCTURE_1oxa| PDB=1oxa | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1oxa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1oxa OCA], [http://www.ebi.ac.uk/pdbsum/1oxa PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1oxa RCSB]</span>
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'''CYTOCHROME P450 (DONOR:O2 OXIDOREDUCTASE)'''
'''CYTOCHROME P450 (DONOR:O2 OXIDOREDUCTASE)'''
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[[Category: Cupp-Vickery, J R.]]
[[Category: Cupp-Vickery, J R.]]
[[Category: Poulos, T L.]]
[[Category: Poulos, T L.]]
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[[Category: oxidoreductase (oxygenase)]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 04:23:26 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:51:40 2008''
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Revision as of 01:23, 3 May 2008

Image:1oxa.jpg

Template:STRUCTURE 1oxa

CYTOCHROME P450 (DONOR:O2 OXIDOREDUCTASE)


Overview

Cytochrome P450eryF catalyzes the 6S-hydroxylation of 6-deoxyerythronolide B, the initial reaction in a multistep pathway to convert 6-deoxyerythronolide B into the antibiotic, erythromycin. The overall structure of P450eryF is similar to that of P450cam but differs in the exact positioning of several alpha-helices. The largest difference occurs in the B' helix and results in the enlargement of the substrate-binding pocket of P450eryF. The substrate is positioned with the macrolide ring perpendicular to the haem plane and contacts seven hydrophobic residues and three solvent molecules. The substrate participates in a network of hydrogen bonds that may provide a proton shuttle pathway in the oxygen cleavage reaction.

About this Structure

1OXA is a Single protein structure of sequence from Saccharopolyspora erythraea. Full crystallographic information is available from OCA.

Reference

Structure of cytochrome P450eryF involved in erythromycin biosynthesis., Cupp-Vickery JR, Poulos TL, Nat Struct Biol. 1995 Feb;2(2):144-53. PMID:7749919 Page seeded by OCA on Sat May 3 04:23:26 2008

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