1oxb

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[[Image:1oxb.jpg|left|200px]]
[[Image:1oxb.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 1oxb |SIZE=350|CAPTION= <scene name='initialview01'>1oxb</scene>, resolution 2.30&Aring;
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The line below this paragraph, containing "STRUCTURE_1oxb", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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|GENE= YPD1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae]), SLN1 OR YPD2 OR YIL147C ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae])
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|DOMAIN=
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{{STRUCTURE_1oxb| PDB=1oxb | SCENE= }}
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|RELATEDENTRY=[[1qsp|1QSP]], [[1oxk|1OXK]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1oxb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1oxb OCA], [http://www.ebi.ac.uk/pdbsum/1oxb PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1oxb RCSB]</span>
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}}
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'''Complex between YPD1 and SLN1 response regulator domain in space group P2(1)2(1)2(1)'''
'''Complex between YPD1 and SLN1 response regulator domain in space group P2(1)2(1)2(1)'''
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[[Category: West, A H.]]
[[Category: West, A H.]]
[[Category: Xu, Q.]]
[[Category: Xu, Q.]]
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[[Category: histidine-containing phosphotransfer protein]]
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[[Category: Histidine-containing phosphotransfer protein]]
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[[Category: hpt domain]]
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[[Category: Hpt domain]]
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[[Category: phosphorelay protein]]
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[[Category: Phosphorelay protein]]
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[[Category: response regulator]]
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[[Category: Response regulator]]
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[[Category: sln1p]]
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[[Category: Sln1p]]
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[[Category: two-component signaling protein]]
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[[Category: Two-component signaling protein]]
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[[Category: ypd1p]]
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[[Category: Ypd1p]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 04:23:32 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:51:43 2008''
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Revision as of 01:23, 3 May 2008

Image:1oxb.jpg

Template:STRUCTURE 1oxb

Complex between YPD1 and SLN1 response regulator domain in space group P2(1)2(1)2(1)


Overview

In Saccharomyces cerevisiae, a branched multistep phosphorelay signaling pathway regulates cellular adaptation to hyperosmotic stress. YPD1 functions as a histidine-phosphorylated protein intermediate required for phosphoryl group transfer from a membrane-bound sensor histidine kinase (SLN1) to two distinct response regulator proteins (SSK1 and SKN7). These four proteins are evolutionarily related to the well-characterized "two-component" regulatory proteins from bacteria. Although structural information is available for many two-component signaling proteins, there are very few examples of complexes between interacting phosphorelay partners. Here we report the first crystal structure of a prototypical monomeric histidine-containing phosphotransfer (HPt) protein YPD1 in complex with its upstream phosphodonor, the response regulator domain associated with SLN1.

About this Structure

1OXB is a Protein complex structure of sequences from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

The yeast YPD1/SLN1 complex: insights into molecular recognition in two-component signaling systems., Xu Q, Porter SW, West AH, Structure. 2003 Dec;11(12):1569-81. PMID:14656441 Page seeded by OCA on Sat May 3 04:23:32 2008

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