1oxc

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[[Image:1oxc.jpg|left|200px]]
[[Image:1oxc.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 1oxc |SIZE=350|CAPTION= <scene name='initialview01'>1oxc</scene>, resolution 1.2&Aring;
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The line below this paragraph, containing "STRUCTURE_1oxc", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=FUL:BETA-L-FUCOSE'>FUL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE= LecB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=287 Pseudomonas aeruginosa])
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-->
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|DOMAIN=
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{{STRUCTURE_1oxc| PDB=1oxc | SCENE= }}
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|RELATEDENTRY=[[1gzt|1GZT]], [[1our|1OUR]], [[1ous|1OUS]], [[1oux|1OUX]], [[1ovp|1OVP]], [[1ovs|1OVS]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1oxc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1oxc OCA], [http://www.ebi.ac.uk/pdbsum/1oxc PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1oxc RCSB]</span>
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}}
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'''LecB (PA-LII) in complex with FUCOSE'''
'''LecB (PA-LII) in complex with FUCOSE'''
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[[Category: Tielker, D.]]
[[Category: Tielker, D.]]
[[Category: Wyns, L.]]
[[Category: Wyns, L.]]
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[[Category: carbohydrate]]
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[[Category: Carbohydrate]]
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[[Category: lectin]]
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[[Category: Lectin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 04:23:34 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:51:47 2008''
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Revision as of 01:23, 3 May 2008

Image:1oxc.jpg

Template:STRUCTURE 1oxc

LecB (PA-LII) in complex with FUCOSE


Overview

The crystal structure of Pseudomonas aeruginosa fucose-specific lectin LecB was determined in its metal-bound and metal-free state as well as in complex with fucose, mannose and fructopyranose. All three monosaccharides bind isosterically via direct interactions with two calcium ions as well as direct hydrogen bonds with several side-chains. The higher affinity for fucose is explained by the details of the binding site around C6 and O1 of fucose. In the mannose and fructose complexes, a carboxylate oxygen atom and one or two hydroxyl groups are partly shielded from solvent upon sugar binding, preventing them from completely fulfilling their hydrogen bonding potential. In the fucose complex, no such defects are observed. Instead, C6 makes favourable interactions with a small hydrophobic patch. Upon demetallization, the C terminus as well as the otherwise rigid metal-binding loop become more mobile and adopt multiple conformations.

About this Structure

1OXC is a Single protein structure of sequence from Pseudomonas aeruginosa. Full crystallographic information is available from OCA.

Reference

Structural basis of carbohydrate recognition by the lectin LecB from Pseudomonas aeruginosa., Loris R, Tielker D, Jaeger KE, Wyns L, J Mol Biol. 2003 Aug 22;331(4):861-70. PMID:12909014 Page seeded by OCA on Sat May 3 04:23:34 2008

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