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2jbg

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Current revision (14:41, 13 December 2023) (edit) (undo)
 
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<StructureSection load='2jbg' size='340' side='right'caption='[[2jbg]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
<StructureSection load='2jbg' size='340' side='right'caption='[[2jbg]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2jbg]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JBG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JBG FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2jbg]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_str._K-12_substr._W3110 Escherichia coli str. K-12 substr. W3110]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JBG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JBG FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1m08|1m08]], [[1pt3|1pt3]], [[1zns|1zns]], [[2axc|2axc]], [[2ivh|2ivh]], [[1ayi|1ayi]], [[1cei|1cei]], [[1mz8|1mz8]], [[1ujz|1ujz]], [[1unk|1unk]], [[1znv|1znv]], [[2erh|2erh]], [[2jaz|2jaz]], [[2jb0|2jb0]], [[7cei|7cei]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jbg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jbg OCA], [https://pdbe.org/2jbg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jbg RCSB], [https://www.ebi.ac.uk/pdbsum/2jbg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jbg ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jbg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jbg OCA], [https://pdbe.org/2jbg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jbg RCSB], [https://www.ebi.ac.uk/pdbsum/2jbg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jbg ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/IMM7_ECOLX IMM7_ECOLX]] This protein is able to protect a cell, which harbors the plasmid ColE7 encoding colicin E7, against colicin E7, it binds specifically to the DNase-type colicin and inhibits its bactericidal activity. Dimeric ImmE7 may possess a RNase activity that cleaves its own mRNA at a specific site and thus autoregulates translational expression of the downstream ceiE7 gene as well as degradation of the upstream ceaE7 mRNA. [[https://www.uniprot.org/uniprot/CEA7_ECOLX CEA7_ECOLX]] This plasmid-coded bactericidal protein is an endonuclease active on both single- and double-stranded DNA but with undefined specificity. Colicins are polypeptide toxins produced by and active against E.coli and closely related bacteria.
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[https://www.uniprot.org/uniprot/IMM7_ECOLX IMM7_ECOLX] This protein is able to protect a cell, which harbors the plasmid ColE7 encoding colicin E7, against colicin E7, it binds specifically to the DNase-type colicin and inhibits its bactericidal activity. Dimeric ImmE7 may possess a RNase activity that cleaves its own mRNA at a specific site and thus autoregulates translational expression of the downstream ceiE7 gene as well as degradation of the upstream ceaE7 mRNA.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Escherichia coli str. K-12 substr. W3110]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Huang, H]]
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[[Category: Huang H]]
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[[Category: Yuan, H S]]
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[[Category: Yuan HS]]
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[[Category: Antibiotic]]
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[[Category: Antimicrobial]]
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[[Category: Bacteriocin]]
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[[Category: Bacteriocin immunity]]
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[[Category: Dna hydrolysis]]
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[[Category: Endonuclease]]
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[[Category: H-n-h motif]]
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[[Category: His metal finger motif]]
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[[Category: Hydrolase]]
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[[Category: Hydrolase-inhibitor complex]]
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[[Category: Hydrolase/inhibitor]]
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[[Category: Metal-binding]]
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[[Category: Nuclease]]
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[[Category: Plasmid]]
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[[Category: Toxin]]
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[[Category: Zinc]]
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Current revision

crystal structure of the mutant N560A of the nuclease domain of ColE7 in complex with Im7

PDB ID 2jbg

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

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