2jex

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Current revision (14:45, 13 December 2023) (edit) (undo)
 
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<StructureSection load='2jex' size='340' side='right'caption='[[2jex]], [[Resolution|resolution]] 2.35&Aring;' scene=''>
<StructureSection load='2jex' size='340' side='right'caption='[[2jex]], [[Resolution|resolution]] 2.35&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2jex]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JEX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JEX FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2jex]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Deltapapillomavirus_4 Deltapapillomavirus 4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JEX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JEX FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1dbd|1dbd]], [[1jjh|1jjh]], [[2bop|2bop]], [[2jeu|2jeu]]</div></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.35&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jex FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jex OCA], [https://pdbe.org/2jex PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jex RCSB], [https://www.ebi.ac.uk/pdbsum/2jex PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jex ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jex FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jex OCA], [https://pdbe.org/2jex PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jex RCSB], [https://www.ebi.ac.uk/pdbsum/2jex PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jex ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/VE2_BPV1 VE2_BPV1]] E2 regulates viral transcription and DNA replication. Binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. Can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication.
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[https://www.uniprot.org/uniprot/VE2_BPV1 VE2_BPV1] E2 regulates viral transcription and DNA replication. Binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. Can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Deltapapillomavirus 4]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Antson, A A]]
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[[Category: Antson AA]]
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[[Category: Ortiz-Lombardia, M]]
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[[Category: Ortiz-Lombardia M]]
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[[Category: Sanders, C M]]
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[[Category: Sanders CM]]
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[[Category: Seavers, P R]]
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[[Category: Seavers PR]]
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[[Category: Sizov, D]]
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[[Category: Sizov D]]
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[[Category: Activator]]
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[[Category: Bovine papillomavirus]]
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[[Category: Dna replication]]
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[[Category: Dna-binding]]
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[[Category: E1]]
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[[Category: E2]]
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[[Category: Early protein]]
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[[Category: Nuclear protein]]
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[[Category: Oxidation]]
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[[Category: Phosphorylation]]
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[[Category: Redox control]]
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[[Category: Replication initiation]]
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[[Category: Repressor]]
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[[Category: Transcription]]
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[[Category: Transcription regulation]]
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[[Category: Viral transcription factor]]
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Current revision

Transcription activator structure reveals redox control of a replication initiation reaction

PDB ID 2jex

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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