2jfh

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Current revision (14:46, 13 December 2023) (edit) (undo)
 
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<StructureSection load='2jfh' size='340' side='right'caption='[[2jfh]], [[Resolution|resolution]] 1.97&Aring;' scene=''>
<StructureSection load='2jfh' size='340' side='right'caption='[[2jfh]], [[Resolution|resolution]] 1.97&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2jfh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JFH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JFH FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2jfh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JFH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JFH FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LK1:N-[(6-BUTOXYNAPHTHALEN-2-YL)SULFONYL]-L-GLUTAMIC+ACID'>LK1</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.97&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=KCX:LYSINE+NZ-CARBOXYLIC+ACID'>KCX</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=KCX:LYSINE+NZ-CARBOXYLIC+ACID'>KCX</scene>, <scene name='pdbligand=LK1:N-[(6-BUTOXYNAPHTHALEN-2-YL)SULFONYL]-L-GLUTAMIC+ACID'>LK1</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1e0d|1e0d]], [[1eeh|1eeh]], [[1uag|1uag]], [[2uag|2uag]], [[3uag|3uag]], [[4uag|4uag]], [[2jff|2jff]], [[2jfg|2jfg]]</div></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/UDP-N-acetylmuramoyl-L-alanine--D-glutamate_ligase UDP-N-acetylmuramoyl-L-alanine--D-glutamate ligase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.2.9 6.3.2.9] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jfh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jfh OCA], [https://pdbe.org/2jfh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jfh RCSB], [https://www.ebi.ac.uk/pdbsum/2jfh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jfh ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jfh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jfh OCA], [https://pdbe.org/2jfh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jfh RCSB], [https://www.ebi.ac.uk/pdbsum/2jfh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jfh ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MURD_ECOLI MURD_ECOLI] Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).[HAMAP-Rule:MF_00639]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Bacillus coli migula 1895]]
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[[Category: Escherichia coli]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: UDP-N-acetylmuramoyl-L-alanine--D-glutamate ligase]]
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[[Category: Blanot D]]
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[[Category: Blanot, D]]
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[[Category: Contreras-Martel C]]
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[[Category: Contreras-Martel, C]]
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[[Category: Dessen A]]
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[[Category: Dessen, A]]
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[[Category: Gobec S]]
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[[Category: Gobec, S]]
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[[Category: Herve M]]
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[[Category: Herve, M]]
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[[Category: Humljan J]]
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[[Category: Humljan, J]]
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[[Category: Kotnik M]]
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[[Category: Kotnik, M]]
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[[Category: Kristan K]]
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[[Category: Kristan, K]]
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[[Category: Oblak M]]
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[[Category: Oblak, M]]
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[[Category: Solmajer T]]
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[[Category: Solmajer, T]]
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[[Category: Urleb U]]
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[[Category: Urleb, U]]
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[[Category: Atp-binding]]
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[[Category: Cell cycle]]
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[[Category: Cell division]]
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[[Category: Cell shape]]
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[[Category: Cell wall]]
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[[Category: Ligase]]
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[[Category: Murd ligase]]
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[[Category: Murd-inhibitor complex]]
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[[Category: Nucleotide-binding]]
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[[Category: Peptidoglycan synthesis]]
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[[Category: Sulfonamide inhibitor]]
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Current revision

Crystal structure of MurD ligase in complex with L-Glu containing sulfonamide inhibitor

PDB ID 2jfh

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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