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2uzx

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Current revision

Structure of the human receptor tyrosine kinase Met in complex with the Listeria monocytogenes invasion protein InlB: Crystal form I

Structural highlights

2uzx is a 4 chain structure with sequence from Homo sapiens and Listeria monocytogenes EGD-e. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 2.8Å
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

INLB_LISMO Mediates the entry of Listeria monocytogenes into cells.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

The tyrosine kinase Met, the product of the c-met proto-oncogene and the receptor for hepatocyte growth factor/scatter factor (HGF/SF), mediates signals critical for cell survival and migration. The human pathogen Listeria monocytogenes exploits Met signaling for invasion of host cells via its surface protein InlB. We present the crystal structure of the complex between a large fragment of the human Met ectodomain and the Met-binding domain of InlB. The concave face of the InlB leucine-rich repeat region interacts tightly with the first immunoglobulin-like domain of the Met stalk, a domain which does not bind HGF/SF. A second contact between InlB and the Met Sema domain locks the otherwise flexible receptor in a rigid, signaling competent conformation. Full Met activation requires the additional C-terminal domains of InlB which induce heparin-mediated receptor clustering and potent signaling. Thus, although it elicits a similar cellular response, InlB is not a structural mimic of HGF/SF.

Structure of the human receptor tyrosine kinase met in complex with the Listeria invasion protein InlB.,Niemann HH, Jager V, Butler PJ, van den Heuvel J, Schmidt S, Ferraris D, Gherardi E, Heinz DW Cell. 2007 Jul 27;130(2):235-46. PMID:17662939^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Niemann HH, Jager V, Butler PJ, van den Heuvel J, Schmidt S, Ferraris D, Gherardi E, Heinz DW. Structure of the human receptor tyrosine kinase met in complex with the Listeria invasion protein InlB. Cell. 2007 Jul 27;130(2):235-46. PMID:17662939 doi:10.1016/j.cell.2007.05.037

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 Publication Abstract from PubMed
5 See Also
6 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2uzx"

@@ Line 3: / Line 3: @@
 <StructureSection load='2uzx' size='340' side='right'caption='[[2uzx]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[2uzx]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human] and [https://en.wikipedia.org/wiki/Lismo Lismo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UZX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2UZX FirstGlance]. <br>
+<table><tr><td colspan='2'>[[2uzx]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Listeria_monocytogenes_EGD-e Listeria monocytogenes EGD-e]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UZX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2UZX FirstGlance]. <br>
-</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1d0b|1d0b]], [[1fyr|1fyr]], [[1h6t|1h6t]], [[1m9s|1m9s]], [[1otm|1otm]], [[1otn|1otn]], [[1oto|1oto]], [[1r0p|1r0p]], [[1r1w|1r1w]], [[1shy|1shy]], [[1ssl|1ssl]], [[1ux3|1ux3]], [[2cew|2cew]], [[2g15|2g15]], [[2uzy|2uzy]]</div></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
 <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2uzx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2uzx OCA], [https://pdbe.org/2uzx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2uzx RCSB], [https://www.ebi.ac.uk/pdbsum/2uzx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2uzx ProSAT]</span></td></tr>
 </table>
+== Function ==
+[https://www.uniprot.org/uniprot/INLB_LISMO INLB_LISMO] Mediates the entry of Listeria monocytogenes into cells.
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
@@ Line 33: / Line 35: @@
 __TOC__
 </StructureSection>
-[[Category: Human]]
+[[Category: Homo sapiens]]
 [[Category: Large Structures]]
-[[Category: Lismo]]
+[[Category: Listeria monocytogenes EGD-e]]
-[[Category: Butler, P J.G]]
+[[Category: Butler PJG]]
-[[Category: Ferraris, D]]
+[[Category: Ferraris D]]
-[[Category: Gherardi, E]]
+[[Category: Gherardi E]]
-[[Category: Heinz, D W]]
+[[Category: Heinz DW]]
-[[Category: Heuvel, J Van Den]]
+[[Category: Jager V]]
-[[Category: Jager, V]]
+[[Category: Niemann HH]]
-[[Category: Niemann, H H]]
+[[Category: Schmidt S]]
-[[Category: Schmidt, S]]
+[[Category: Van Den Heuvel J]]
-[[Category: Alternative splicing]]
-[[Category: Atp-binding]]
-[[Category: Chromosomal rearrangement]]
-[[Category: Disease mutation]]
-[[Category: Glycoprotein]]
-[[Category: Hepatocyte growth factor receptor]]
-[[Category: Hgfr]]
-[[Category: Internalin]]
-[[Category: Kinase]]
-[[Category: Leucine rich repeat]]
-[[Category: Leucine-rich repeat]]
-[[Category: Lrr]]
-[[Category: Membrane]]
-[[Category: Nucleotide-binding]]
-[[Category: Phosphorylation]]
-[[Category: Polymorphism]]
-[[Category: Proto-oncogene]]
-[[Category: Receptor]]
-[[Category: Receptor ectodomain]]
-[[Category: Signaling protein]]
-[[Category: Signaling protein-receptor complex]]
-[[Category: Signaling protein/receptor]]
-[[Category: Transferase]]
-[[Category: Transmembrane]]
-[[Category: Tyrosine-protein kinase]]
-[[Category: Virulence factor]]

2uzx

From Proteopedia

Current revision

Structure of the human receptor tyrosine kinase Met in complex with the Listeria monocytogenes invasion protein InlB: Crystal form I

Structural highlights

Function

Evolutionary Conservation

Publication Abstract from PubMed

See Also

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

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