2v4u
From Proteopedia
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<StructureSection load='2v4u' size='340' side='right'caption='[[2v4u]], [[Resolution|resolution]] 2.30Å' scene=''> | <StructureSection load='2v4u' size='340' side='right'caption='[[2v4u]], [[Resolution|resolution]] 2.30Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2v4u]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[2v4u]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V4U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2V4U FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3Å</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CYD:2-AMINO-6-(CYSTEIN-S-YL)-5-OXO-HEXANOIC+ACID'>CYD</scene></td></tr> |
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2v4u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v4u OCA], [https://pdbe.org/2v4u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2v4u RCSB], [https://www.ebi.ac.uk/pdbsum/2v4u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2v4u ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2v4u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v4u OCA], [https://pdbe.org/2v4u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2v4u RCSB], [https://www.ebi.ac.uk/pdbsum/2v4u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2v4u ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/PYRG2_HUMAN PYRG2_HUMAN] Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Constitutes the rate-limiting enzyme in the synthesis of cytosine nucleotides.<ref>PMID:10899599</ref> <ref>PMID:16179339</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2v4u ConSurf]. | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2v4u ConSurf]. | ||
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Andersson | + | [[Category: Andersson J]] |
| - | [[Category: Arrowsmith | + | [[Category: Arrowsmith CH]] |
| - | + | [[Category: Berglund H]] | |
| - | [[Category: Berglund | + | [[Category: Collins R]] |
| - | [[Category: Collins | + | [[Category: Dahlgren LG]] |
| - | [[Category: Dahlgren | + | [[Category: Edwards AM]] |
| - | [[Category: Edwards | + | [[Category: Flodin S]] |
| - | [[Category: Flodin | + | [[Category: Flores A]] |
| - | [[Category: Flores | + | [[Category: Graslund S]] |
| - | [[Category: Graslund | + | [[Category: Hammarstrom M]] |
| - | [[Category: Hammarstrom | + | [[Category: Johansson A]] |
| - | [[Category: Johansson | + | [[Category: Johansson I]] |
| - | [[Category: Johansson | + | [[Category: Karlberg T]] |
| - | [[Category: Karlberg | + | [[Category: Kotenyova T]] |
| - | [[Category: Kotenyova | + | [[Category: Lehtio L]] |
| - | [[Category: Lehtio | + | [[Category: Moche M]] |
| - | [[Category: Moche | + | [[Category: Nilsson ME]] |
| - | [[Category: Nilsson | + | [[Category: Nordlund P]] |
| - | [[Category: Nordlund | + | [[Category: Nyman T]] |
| - | [[Category: Nyman | + | [[Category: Olesen K]] |
| - | [[Category: Olesen | + | [[Category: Persson C]] |
| - | [[Category: Persson | + | [[Category: Sagemark J]] |
| - | [[Category: Sagemark | + | [[Category: Schueler H]] |
| - | [[Category: Schueler | + | [[Category: Thorsell AG]] |
| - | [[Category: Thorsell | + | [[Category: Tresaugues L]] |
| - | [[Category: Tresaugues | + | [[Category: Van Den Berg S]] |
| - | [[Category: | + | [[Category: Weigelt J]] |
| - | [[Category: | + | [[Category: Welin M]] |
| - | [[Category: | + | [[Category: Wikstrom M]] |
| - | [[Category: | + | [[Category: Wisniewska M]] |
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Current revision
Human CTP synthetase 2 - glutaminase domain in complex with 5-OXO-L- NORLEUCINE
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Categories: Homo sapiens | Large Structures | Andersson J | Arrowsmith CH | Berglund H | Collins R | Dahlgren LG | Edwards AM | Flodin S | Flores A | Graslund S | Hammarstrom M | Johansson A | Johansson I | Karlberg T | Kotenyova T | Lehtio L | Moche M | Nilsson ME | Nordlund P | Nyman T | Olesen K | Persson C | Sagemark J | Schueler H | Thorsell AG | Tresaugues L | Van Den Berg S | Weigelt J | Welin M | Wikstrom M | Wisniewska M
