2v60

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<StructureSection load='2v60' size='340' side='right'caption='[[2v60]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
<StructureSection load='2v60' size='340' side='right'caption='[[2v60]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2v60]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V60 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2V60 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2v60]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V60 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2V60 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=C17:7-[(3-CHLOROBENZYL)OXY]-2-OXO-2H-CHROMENE-4-CARBALDEHYDE'>C17</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1gos|1gos]], [[1h8r|1h8r]], [[1oj9|1oj9]], [[1oja|1oja]], [[1ojb|1ojb]], [[1ojc|1ojc]], [[1ojd|1ojd]], [[1s2q|1s2q]], [[1s2y|1s2y]], [[1s3b|1s3b]], [[1s3e|1s3e]], [[2bk3|2bk3]], [[2bk4|2bk4]], [[2bk5|2bk5]], [[2byb|2byb]], [[2c64|2c64]], [[2c65|2c65]], [[2c66|2c66]], [[2c67|2c67]], [[2c70|2c70]], [[2c72|2c72]], [[2c73|2c73]], [[2c75|2c75]], [[2c76|2c76]], [[2v5z|2v5z]], [[2v61|2v61]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=C17:7-[(3-CHLOROBENZYL)OXY]-2-OXO-2H-CHROMENE-4-CARBALDEHYDE'>C17</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Monoamine_oxidase Monoamine oxidase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.4.3.4 1.4.3.4] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2v60 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v60 OCA], [https://pdbe.org/2v60 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2v60 RCSB], [https://www.ebi.ac.uk/pdbsum/2v60 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2v60 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2v60 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v60 OCA], [https://pdbe.org/2v60 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2v60 RCSB], [https://www.ebi.ac.uk/pdbsum/2v60 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2v60 ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/AOFB_HUMAN AOFB_HUMAN] Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOB preferentially degrades benzylamine and phenylethylamine.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Monoamine oxidase]]
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[[Category: Binda C]]
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[[Category: Binda, C]]
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[[Category: Caccia C]]
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[[Category: Caccia, C]]
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[[Category: Carotti A]]
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[[Category: Carotti, A]]
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[[Category: Edmondson DE]]
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[[Category: Edmondson, D E]]
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[[Category: Mattevi A]]
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[[Category: Mattevi, A]]
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[[Category: Pisani L]]
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[[Category: Pisani, L]]
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[[Category: Salvati P]]
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[[Category: Salvati, P]]
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[[Category: Wang J]]
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[[Category: Wang, J]]
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[[Category: Fad]]
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[[Category: Flavoprotein]]
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[[Category: Human mao b structure]]
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[[Category: Membrane]]
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[[Category: Mitochondrion]]
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[[Category: Neuroprotection]]
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[[Category: Oxidoreductase]]
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[[Category: Parkinson's disease]]
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[[Category: Reversible inhibitor binding]]
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[[Category: Safinamide]]
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[[Category: Transmembrane]]
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Revision as of 15:07, 13 December 2023

Structure of human MAO B in complex with the selective inhibitor 7-(3- chlorobenzyloxy)-4-carboxaldehyde-coumarin

PDB ID 2v60

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OCA

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