2v61
From Proteopedia
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<StructureSection load='2v61' size='340' side='right'caption='[[2v61]], [[Resolution|resolution]] 1.70Å' scene=''> | <StructureSection load='2v61' size='340' side='right'caption='[[2v61]], [[Resolution|resolution]] 1.70Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
- | <table><tr><td colspan='2'>[[2v61]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[2v61]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V61 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2V61 FirstGlance]. <br> |
- | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7Å</td></tr> |
- | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=C18:7-[(3-CHLOROBENZYL)OXY]-4-[(METHYLAMINO)METHYL]-2H-CHROMEN-2-ONE'>C18</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr> |
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2v61 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v61 OCA], [https://pdbe.org/2v61 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2v61 RCSB], [https://www.ebi.ac.uk/pdbsum/2v61 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2v61 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2v61 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v61 OCA], [https://pdbe.org/2v61 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2v61 RCSB], [https://www.ebi.ac.uk/pdbsum/2v61 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2v61 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
+ | == Function == | ||
+ | [https://www.uniprot.org/uniprot/AOFB_HUMAN AOFB_HUMAN] Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOB preferentially degrades benzylamine and phenylethylamine. | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
- | [[Category: | + | [[Category: Homo sapiens]] |
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
- | + | [[Category: Binda C]] | |
- | [[Category: Binda | + | [[Category: Caccia C]] |
- | [[Category: Caccia | + | [[Category: Carotti A]] |
- | [[Category: Carotti | + | [[Category: Edmondson DE]] |
- | [[Category: Edmondson | + | [[Category: Mattevi A]] |
- | [[Category: Mattevi | + | [[Category: Pisani L]] |
- | [[Category: Pisani | + | [[Category: Salvati P]] |
- | [[Category: Salvati | + | [[Category: Wang J]] |
- | [[Category: Wang | + | |
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Revision as of 15:07, 13 December 2023
Structure of human MAO B in complex with the selective inhibitor 7-(3- chlorobenzyloxy)-4-(methylamino)methyl-coumarin
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Categories: Homo sapiens | Large Structures | Binda C | Caccia C | Carotti A | Edmondson DE | Mattevi A | Pisani L | Salvati P | Wang J