1oyu
From Proteopedia
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[[Image:1oyu.jpg|left|200px]] | [[Image:1oyu.jpg|left|200px]] | ||
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'''Long-Distance conformational changes in a protein engineered by modulated sequence duplication''' | '''Long-Distance conformational changes in a protein engineered by modulated sequence duplication''' | ||
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[[Category: Matthews, B W.]] | [[Category: Matthews, B W.]] | ||
[[Category: Sagermann, M.]] | [[Category: Sagermann, M.]] | ||
| - | [[Category: | + | [[Category: Design of structural switch]] |
| - | [[Category: | + | [[Category: Protein design]] |
| - | [[Category: | + | [[Category: Sequence duplication]] |
| - | [[Category: | + | [[Category: Tandem repeat]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 04:26:45 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 01:26, 3 May 2008
Long-Distance conformational changes in a protein engineered by modulated sequence duplication
Overview
There are few, if any, known instances in which a biological signal is transmitted via a large conformational change through the body of a protein. We describe here a mutant of T4 lysozyme that was engineered to permit structural change at a distance. The design uses a tandem sequence repeat that makes it possible to transmit large-scale structural changes from one end of an alpha-helix to the other over a distance of 17-25 A. The method should be of general applicability and may make it possible to introduce a mutation at one site in a protein that will induce large-scale changes in the structure at a spatially remote site.
About this Structure
1OYU is a Single protein structure of sequence from Enterobacteria phage t4. Full crystallographic information is available from OCA.
Reference
Long-distance conformational changes in a protein engineered by modulated sequence duplication., Sagermann M, Gay L, Matthews BW, Proc Natl Acad Sci U S A. 2003 Aug 5;100(16):9191-5. Epub 2003 Jul 17. PMID:12869697 Page seeded by OCA on Sat May 3 04:26:45 2008
