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1oyt

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[[Image:1oyt.jpg|left|200px]]
[[Image:1oyt.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 1oyt |SIZE=350|CAPTION= <scene name='initialview01'>1oyt</scene>, resolution 1.67&Aring;
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The line below this paragraph, containing "STRUCTURE_1oyt", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FSN:(3ASR,4RS,8ASR,8BRS)-4-(2-(4-FLUOROBENZYL)-1,3-DIOXODEACAHYDROPYRROLO[3,4-A]+PYRROLIZIN-4-YL)BENZAMIDINE'>FSN</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SIN:SUCCINIC+ACID'>SIN</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Thrombin Thrombin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.5 3.4.21.5] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= F2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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-->
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|DOMAIN=
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{{STRUCTURE_1oyt| PDB=1oyt | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1oyt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1oyt OCA], [http://www.ebi.ac.uk/pdbsum/1oyt PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1oyt RCSB]</span>
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}}
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'''COMPLEX OF RECOMBINANT HUMAN THROMBIN WITH A DESIGNED FLUORINATED INHIBITOR'''
'''COMPLEX OF RECOMBINANT HUMAN THROMBIN WITH A DESIGNED FLUORINATED INHIBITOR'''
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[[Category: Banner, D W.]]
[[Category: Banner, D W.]]
[[Category: Olsen, J A.]]
[[Category: Olsen, J A.]]
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[[Category: hydrolase (serine proteinase)]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 04:26:47 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:52:22 2008''
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Revision as of 01:26, 3 May 2008

Image:1oyt.jpg

Template:STRUCTURE 1oyt

COMPLEX OF RECOMBINANT HUMAN THROMBIN WITH A DESIGNED FLUORINATED INHIBITOR


Disease

Known disease associated with this structure: Dysprothrombinemia OMIM:[176930], Hyperprothrombinemia OMIM:[176930], Hypoprothrombinemia OMIM:[176930]

About this Structure

1OYT is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

A fluorine scan of thrombin inhibitors to map the fluorophilicity/fluorophobicity of an enzyme active site: evidence for C-F...C=O interactions., Olsen JA, Banner DW, Seiler P, Obst Sander U, D'Arcy A, Stihle M, Muller K, Diederich F, Angew Chem Int Ed Engl. 2003 Jun 6;42(22):2507-11. PMID:12800172 Page seeded by OCA on Sat May 3 04:26:47 2008

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OCA

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