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2vot

From Proteopedia

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Current revision (15:27, 13 December 2023) (edit) (undo)
 
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<StructureSection load='2vot' size='340' side='right'caption='[[2vot]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
<StructureSection load='2vot' size='340' side='right'caption='[[2vot]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2vot]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bactn Bactn]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VOT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VOT FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2vot]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacteroides_thetaiotaomicron_VPI-5482 Bacteroides thetaiotaomicron VPI-5482]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VOT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VOT FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BR:BROMIDE+ION'>BR</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NHV:(5R,6R,7S,8R)-6,7,8-TRIHYDROXY-5-(HYDROXYMETHYL)-2-[(PHENYLAMINO)METHYL]-5,6,7,8-TETRAHYDRO-1H-IMIDAZO[1,2-A]PYRIDIN-4-IUM'>NHV</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2vqt|2vqt]], [[2vl4|2vl4]], [[2vqu|2vqu]], [[2vo5|2vo5]], [[2je8|2je8]], [[2vjx|2vjx]], [[2vmf|2vmf]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BR:BROMIDE+ION'>BR</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NHV:(5R,6R,7S,8R)-6,7,8-TRIHYDROXY-5-(HYDROXYMETHYL)-2-[(PHENYLAMINO)METHYL]-5,6,7,8-TETRAHYDRO-1H-IMIDAZO[1,2-A]PYRIDIN-4-IUM'>NHV</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Beta-mannosidase Beta-mannosidase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.25 3.2.1.25] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vot FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vot OCA], [https://pdbe.org/2vot PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vot RCSB], [https://www.ebi.ac.uk/pdbsum/2vot PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vot ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vot FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vot OCA], [https://pdbe.org/2vot PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vot RCSB], [https://www.ebi.ac.uk/pdbsum/2vot PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vot ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q8AAK6_BACTN Q8AAK6_BACTN]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Bactn]]
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[[Category: Bacteroides thetaiotaomicron VPI-5482]]
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[[Category: Beta-mannosidase]]
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[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Bleriot, Y]]
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[[Category: Bleriot Y]]
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[[Category: Davies, G J]]
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[[Category: Davies GJ]]
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[[Category: Dumon, C]]
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[[Category: Dumon C]]
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[[Category: Gilbert, H J]]
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[[Category: Gilbert HJ]]
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[[Category: Gratien, J]]
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[[Category: Gratien J]]
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[[Category: Heck, M P]]
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[[Category: Heck M-P]]
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[[Category: Moreland, C]]
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[[Category: Moreland C]]
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[[Category: Offen, W A]]
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[[Category: Offen WA]]
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[[Category: Smith, N]]
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[[Category: Smith N]]
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[[Category: Stick, R V]]
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[[Category: Stick RV]]
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[[Category: Tailford, L N]]
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[[Category: Tailford LN]]
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[[Category: Vasella, A]]
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[[Category: Vasella A]]
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[[Category: Glycoside hydrolase]]
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[[Category: Hydrolase]]
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[[Category: Linear free energy relationship]]
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[[Category: Mannosidase]]
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[[Category: Transition state mimic]]
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Current revision

Structural and biochemical evidence for a boat-like transition state in beta-mannosidases

PDB ID 2vot

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OCA

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