1oz9
From Proteopedia
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'''Crystal structure of AQ_1354, a hypothetical protein from Aquifex aeolicus''' | '''Crystal structure of AQ_1354, a hypothetical protein from Aquifex aeolicus''' | ||
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[[Category: Kim, S H.]] | [[Category: Kim, S H.]] | ||
[[Category: Oganesyan, V.]] | [[Category: Oganesyan, V.]] | ||
| - | [[Category: | + | [[Category: Berkeley structural genomics center]] |
| - | [[Category: | + | [[Category: Bsgc structure funded by nih]] |
| - | [[Category: | + | [[Category: Matrix metalloproteinase type fold]] |
| - | [[Category: | + | [[Category: Protein structure initiative]] |
| - | [[Category: | + | [[Category: Psi]] |
| - | [[Category: | + | [[Category: Structural genomic]] |
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Revision as of 01:27, 3 May 2008
Crystal structure of AQ_1354, a hypothetical protein from Aquifex aeolicus
Overview
The crystal structure of a hypothetical protein AQ_1354 (gi 2983779) from the hyperthermophilic bacteria Aquifex aeolicus has been determined using X-ray crystallography. As found in many structural genomics studies, this protein is not associated with any known function based on its amino-acid sequence. PSI-BLAST analysis against a non-redundant sequence database gave 68 similar sequences referred to as 'conserved hypothetical proteins' from the uncharacterized protein family UPF0054 (accession No. PF02310). Crystallographic analysis revealed that the overall fold of this protein consists of one central alpha-helix surrounded by a four-stranded beta-sheet and four other alpha-helices. Structure-based homology analysis with DALI revealed that the structure has a moderate to good resemblance to metal-dependent proteinases such as collagenases and gelatinases, thus suggesting its possible molecular function. However, experimental tests for collagenase and gelatinase-type function show no detectable activity under standard assay conditions. Therefore, we suggest either that the members of the UPF0054 family have a similar fold but different biochemical functions to those of collagenases and gelatinases or that they have a similar function but perform it under different conditions.
About this Structure
1OZ9 is a Single protein structure of sequence from Aquifex aeolicus. Full crystallographic information is available from OCA.
Reference
Structure of the hypothetical protein AQ_1354 from Aquifex aeolicus., Oganesyan V, Busso D, Brandsen J, Chen S, Jancarik J, Kim R, Kim SH, Acta Crystallogr D Biol Crystallogr. 2003 Jul;59(Pt 7):1219-23. Epub 2003, Jun 27. PMID:12832766 Page seeded by OCA on Sat May 3 04:27:43 2008
Categories: Aquifex aeolicus | Single protein | BSGC, Berkeley Structural Genomics Center. | Brandsen, J. | Busso, D. | Chen, S. | Jancarik, J. | Kim, R. | Kim, S H. | Oganesyan, V. | Berkeley structural genomics center | Bsgc structure funded by nih | Matrix metalloproteinase type fold | Protein structure initiative | Psi | Structural genomic
