1oz8
From Proteopedia
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[[Image:1oz8.gif|left|200px]] | [[Image:1oz8.gif|left|200px]] | ||
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'''Intramolecular higher-order packing of parallel quadruplexes comprising a G:G:G:G tetrad and a G(:A):G(:A):G(:A):G heptad of GGA triplet repeat DNA''' | '''Intramolecular higher-order packing of parallel quadruplexes comprising a G:G:G:G tetrad and a G(:A):G(:A):G(:A):G heptad of GGA triplet repeat DNA''' | ||
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==About this Structure== | ==About this Structure== | ||
| - | + | Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OZ8 OCA]. | |
==Reference== | ==Reference== | ||
Intramolecular higher order packing of parallel quadruplexes comprising a G:G:G:G tetrad and a G(:A):G(:A):G(:A):G heptad of GGA triplet repeat DNA., Matsugami A, Okuizumi T, Uesugi S, Katahira M, J Biol Chem. 2003 Jul 25;278(30):28147-53. Epub 2003 May 14. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12748183 12748183] | Intramolecular higher order packing of parallel quadruplexes comprising a G:G:G:G tetrad and a G(:A):G(:A):G(:A):G heptad of GGA triplet repeat DNA., Matsugami A, Okuizumi T, Uesugi S, Katahira M, J Biol Chem. 2003 Jul 25;278(30):28147-53. Epub 2003 May 14. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12748183 12748183] | ||
| - | [[Category: Protein complex]] | ||
[[Category: Katahira, M.]] | [[Category: Katahira, M.]] | ||
[[Category: Matsugami, A.]] | [[Category: Matsugami, A.]] | ||
[[Category: Okuizumi, T.]] | [[Category: Okuizumi, T.]] | ||
[[Category: Uesugi, S.]] | [[Category: Uesugi, S.]] | ||
| - | [[Category: | + | [[Category: Intramolecular packing of parallel quadruplex]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 04:27:43 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 01:27, 3 May 2008
Intramolecular higher-order packing of parallel quadruplexes comprising a G:G:G:G tetrad and a G(:A):G(:A):G(:A):G heptad of GGA triplet repeat DNA
Overview
GGA triplet repeats are widely dispersed throughout eukaryotic genomes and are frequently located within biologically important regions such as gene regulatory regions and recombination hot spot sites. We determined the structure of d(GGA)4 (12-mer) under physiological conditions and founded the formation of an intramolecular parallel quadruplex for the first time. Later, a similar architecture to that of the intramolecular parallel quadruplex was found for a telomere DNA in the crystalline state. Here, we have determined the structure of d(GGA)8 (24-mer) under physiological conditions. Two intramolecular parallel quadruplexes comprising a G:G:G:G tetrad and a G(:A):G(:A):G(:A):G heptad are formed in d(GGA)8. These quadruplexes are packed in a tail-to-tail manner. This is the first demonstration of the intramolecular higher order packing of quadruplexes at atomic resolution. K+ ions, but not Na+ ones, are critically required for the formation of this unique structure. The elucidated structure suggests the mechanisms underlying the biological events related to the GGA triplet repeat. Furthermore, in the light of the structure, the mode of the higher order packing of the telomere DNA is discussed.
About this Structure
Full crystallographic information is available from OCA.
Reference
Intramolecular higher order packing of parallel quadruplexes comprising a G:G:G:G tetrad and a G(:A):G(:A):G(:A):G heptad of GGA triplet repeat DNA., Matsugami A, Okuizumi T, Uesugi S, Katahira M, J Biol Chem. 2003 Jul 25;278(30):28147-53. Epub 2003 May 14. PMID:12748183 Page seeded by OCA on Sat May 3 04:27:43 2008
