2w3w
From Proteopedia
(Difference between revisions)
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<StructureSection load='2w3w' size='340' side='right'caption='[[2w3w]], [[Resolution|resolution]] 1.60Å' scene=''> | <StructureSection load='2w3w' size='340' side='right'caption='[[2w3w]], [[Resolution|resolution]] 1.60Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2w3w]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[2w3w]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_avium Mycobacterium avium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W3W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2W3W FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=VG9:6-{[(2,5-DIETHOXYPHENYL)AMINO]METHYL}-5-METHYLPYRIDO[2,3-D]PYRIMIDINE-2,4-DIAMINE'>VG9</scene | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6Å</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=VG9:6-{[(2,5-DIETHOXYPHENYL)AMINO]METHYL}-5-METHYLPYRIDO[2,3-D]PYRIMIDINE-2,4-DIAMINE'>VG9</scene></td></tr> | |
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2w3w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w3w OCA], [https://pdbe.org/2w3w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2w3w RCSB], [https://www.ebi.ac.uk/pdbsum/2w3w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2w3w ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2w3w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w3w OCA], [https://pdbe.org/2w3w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2w3w RCSB], [https://www.ebi.ac.uk/pdbsum/2w3w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2w3w ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/O30463_MYCAV O30463_MYCAV] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity).[PIRNR:PIRNR000194] | |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: Bacillus tuberculosis gallinarum sternberg 1892]] | ||
| - | [[Category: Dihydrofolate reductase]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: | + | [[Category: Mycobacterium avium]] |
| - | [[Category: | + | [[Category: Borhani DW]] |
| - | [[Category: | + | [[Category: Leung AKW]] |
| - | [[Category: | + | [[Category: Reynolds RC]] |
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Current revision
MYCOBACTERIUM AVIUM DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND A LIPOPHILIC ANTIFOLATE SELECTIVE FOR M. AVIUM DHFR, 6-((2,5- DIETHOXYPHENYL)AMINOMETHYL)-2,4-DIAMINO-5-METHYLPYRIDO(2,3-D) PYRIMIDINE (SRI-8686)
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