1ozi

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[[Image:1ozi.gif|left|200px]]
[[Image:1ozi.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1ozi |SIZE=350|CAPTION= <scene name='initialview01'>1ozi</scene>
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The line below this paragraph, containing "STRUCTURE_1ozi", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND=
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= PTP-BL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])
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|DOMAIN=
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{{STRUCTURE_1ozi| PDB=1ozi | SCENE= }}
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|RELATEDENTRY=[[1gm1|1GM1]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ozi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ozi OCA], [http://www.ebi.ac.uk/pdbsum/1ozi PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1ozi RCSB]</span>
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}}
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'''The alternatively spliced PDZ2 domain of PTP-BL'''
'''The alternatively spliced PDZ2 domain of PTP-BL'''
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[[Category: Vuister, G W.]]
[[Category: Vuister, G W.]]
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[[Category: Walma, T.]]
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[[Category: adenomatous polyposis coli]]
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[[Category: Adenomatous polyposis coli]]
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[[Category: all-beta protein]]
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[[Category: All-beta protein]]
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[[Category: apc]]
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[[Category: Apc]]
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[[Category: interaction with c-termini]]
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[[Category: Interaction with c-termini]]
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[[Category: pdz domain]]
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[[Category: Pdz domain]]
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[[Category: reversion induced lim]]
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[[Category: Reversion induced lim]]
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[[Category: ril]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 04:28:31 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:52:35 2008''
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Revision as of 01:28, 3 May 2008

Image:1ozi.gif

Template:STRUCTURE 1ozi

The alternatively spliced PDZ2 domain of PTP-BL


Overview

PTP-BL is a large phosphatase that is implicated in cellular processes as diverse as cytokinesis, actin-cytoskeletal rearrangement, and apoptosis. Five PDZ domains mediate its cellular role by binding to the C termini of target proteins, forming multiprotein complexes. The second PDZ domain (PDZ2) binds to the C termini of the tumor suppressor protein APC and the LIM domain-containing protein RIL; however, in one splice variant, PDZ2as, a 5 residue insertion abrogates this binding. The insert causes distinct structural and dynamical changes in the alternatively spliced PDZ2: enlarging the L1 loop between beta2 and beta3, both lengthening and changing the orientation of the alpha2 helix, giving the base of the binding pocket less flexibility to accommodate ligands, and destabilizing the entire domain. These changes render the binding pocket incapable of binding C termini, possibly having implications in the functional role of PTP-BL.

About this Structure

1OZI is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

A closed binding pocket and global destabilization modify the binding properties of an alternatively spliced form of the second PDZ domain of PTP-BL., Walma T, Aelen J, Nabuurs SB, Oostendorp M, van den Berk L, Hendriks W, Vuister GW, Structure. 2004 Jan;12(1):11-20. PMID:14725761 Page seeded by OCA on Sat May 3 04:28:31 2008

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