2w4q

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Current revision (15:43, 13 December 2023) (edit) (undo)
 
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<StructureSection load='2w4q' size='340' side='right'caption='[[2w4q]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
<StructureSection load='2w4q' size='340' side='right'caption='[[2w4q]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2w4q]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W4Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2W4Q FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2w4q]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W4Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2W4Q FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CBW:(3BETA,5BETA,14BETA)-3-HYDROXY-11-OXOOLEAN-12-EN-29-OIC+ACID'>CBW</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/15-oxoprostaglandin_13-oxidase 15-oxoprostaglandin 13-oxidase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.1.48 1.3.1.48] </span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CBW:(3BETA,5BETA,14BETA)-3-HYDROXY-11-OXOOLEAN-12-EN-29-OIC+ACID'>CBW</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2w4q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w4q OCA], [https://pdbe.org/2w4q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2w4q RCSB], [https://www.ebi.ac.uk/pdbsum/2w4q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2w4q ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2w4q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w4q OCA], [https://pdbe.org/2w4q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2w4q RCSB], [https://www.ebi.ac.uk/pdbsum/2w4q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2w4q ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PTGR2_HUMAN PTGR2_HUMAN] Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-keto-PGE1, 15-keto-PGE2, 15-keto-PGE1-alpha and 15-keto-PGE2-alpha with highest activity towards 15-keto-PGE2. Overexpression represses transcriptional activity of PPARG and inhibits adipocyte differentiation (By similarity).<ref>PMID:19000823</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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==See Also==
==See Also==
*[[Alcohol dehydrogenase 3D structures|Alcohol dehydrogenase 3D structures]]
*[[Alcohol dehydrogenase 3D structures|Alcohol dehydrogenase 3D structures]]
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== References ==
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<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: 15-oxoprostaglandin 13-oxidase]]
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[[Category: Homo sapiens]]
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[[Category: Human]]
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[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Arrowsmith, C]]
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[[Category: Arrowsmith C]]
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[[Category: Bountra, C]]
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[[Category: Bountra C]]
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[[Category: Edwards, A]]
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[[Category: Edwards A]]
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[[Category: Niesen, F]]
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[[Category: Niesen F]]
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[[Category: Oppermann, U]]
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[[Category: Oppermann U]]
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[[Category: Picaud, S]]
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[[Category: Picaud S]]
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[[Category: Shafqat, N]]
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[[Category: Shafqat N]]
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[[Category: Ugochukwu, E]]
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[[Category: Ugochukwu E]]
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[[Category: Weigelt, J]]
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[[Category: Weigelt J]]
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[[Category: Yue, W W]]
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[[Category: Yue WW]]
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[[Category: 15-oxoprostalglandin]]
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[[Category: Medium-chain dehydrogenase/reductase]]
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[[Category: Nadp]]
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[[Category: Oxidoreductase]]
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Current revision

Crystal structure of human zinc-binding alcohol dehydrogenase 1 (ZADH1) in ternary complex with NADP and 18beta-glycyrrhetinic acid

PDB ID 2w4q

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Proteopedia Page Contributors and Editors (what is this?)

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