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1ok8
From Proteopedia
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(New page: 200px<br /> <applet load="1ok8" size="450" color="white" frame="true" align="right" spinBox="true" caption="1ok8, resolution 2.00Å" /> '''CRYSTAL STRUCTURE O...)
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Revision as of 16:21, 29 October 2007
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CRYSTAL STRUCTURE OF THE DENGUE 2 VIRUS ENVELOPE GLYCOPROTEIN IN THE POSTFUSION CONFORMATION
Overview
Dengue virus enters a host cell when the viral envelope glycoprotein, E, binds to a receptor and responds by conformational rearrangement to the, reduced pH of an endosome. The conformational change induces fusion of, viral and host-cell membranes. A three-dimensional structure of the, soluble E ectodomain (sE) in its trimeric, postfusion state reveals, striking differences from the dimeric, prefusion form. The elongated, trimer bears three 'fusion loops' at one end, to insert into the host-cell, membrane. Their structure allows us to model directly how these fusion, loops interact with a lipid bilayer. The protein folds back on itself, directing its carboxy terminus towards the fusion loops. We propose a, fusion mechanism driven by essentially irreversible conformational changes, in E ... [(full description)]
About this Structure
1OK8 is a [Single protein] structure of sequence from [Dengue virus type 2] with NAG and CL as [ligands]. Full crystallographic information is available from [OCA].
Reference
Structure of the dengue virus envelope protein after membrane fusion., Modis Y, Ogata S, Clements D, Harrison SC, Nature. 2004 Jan 22;427(6972):313-9. PMID:14737159
Page seeded by OCA on Mon Oct 29 18:26:10 2007
