2wba

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Current revision (15:50, 13 December 2023) (edit) (undo)
 
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<StructureSection load='2wba' size='340' side='right'caption='[[2wba]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
<StructureSection load='2wba' size='340' side='right'caption='[[2wba]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2wba]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Trybb Trybb]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2ve2 2ve2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WBA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WBA FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2wba]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_brucei_brucei Trypanosoma brucei brucei]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2ve2 2ve2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WBA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WBA FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Trypanothione-disulfide_reductase Trypanothione-disulfide reductase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.8.1.12 1.8.1.12] </span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wba FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wba OCA], [https://pdbe.org/2wba PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wba RCSB], [https://www.ebi.ac.uk/pdbsum/2wba PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wba ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wba FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wba OCA], [https://pdbe.org/2wba PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wba RCSB], [https://www.ebi.ac.uk/pdbsum/2wba PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wba ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TYTR_TRYBB TYTR_TRYBB] Trypanothione is the parasite analog of glutathione; this enzyme is the equivalent of glutathione reductase.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Trybb]]
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[[Category: Trypanosoma brucei brucei]]
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[[Category: Trypanothione-disulfide reductase]]
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[[Category: Ariza A]]
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[[Category: Ariza, A]]
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[[Category: Chow WHA]]
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[[Category: Chow, W H.A]]
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[[Category: Fairlamb AH]]
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[[Category: Fairlamb, A H]]
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[[Category: Jones D]]
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[[Category: Jones, D]]
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[[Category: Oza SL]]
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[[Category: Oza, S L]]
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[[Category: Flavoprotein]]
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[[Category: Oxidoreductase]]
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[[Category: Redox-active center]]
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[[Category: Trypnothione metabolism oxidoreductase]]
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Current revision

Properties of Trypanothione Reductase From T. brucei

PDB ID 2wba

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