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2wbb

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Current revision (15:50, 13 December 2023) (edit) (undo)
 
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<StructureSection load='2wbb' size='340' side='right'caption='[[2wbb]], [[Resolution|resolution]] 2.22&Aring;' scene=''>
<StructureSection load='2wbb' size='340' side='right'caption='[[2wbb]], [[Resolution|resolution]] 2.22&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2wbb]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WBB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WBB FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2wbb]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WBB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WBB FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=RO3:N-{[(2Z)-5-BROMO-1,3-THIAZOL-2(3H)-YLIDENE]CARBAMOYL}-4-METHYLBENZENESULFONAMIDE'>RO3</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.22&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2jjk|2jjk]], [[1fta|1fta]], [[2vt5|2vt5]], [[2fie|2fie]], [[2fix|2fix]], [[2fhy|2fhy]], [[2wbd|2wbd]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=RO3:N-{[(2Z)-5-BROMO-1,3-THIAZOL-2(3H)-YLIDENE]CARBAMOYL}-4-METHYLBENZENESULFONAMIDE'>RO3</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Fructose-bisphosphatase Fructose-bisphosphatase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.11 3.1.3.11] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wbb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wbb OCA], [https://pdbe.org/2wbb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wbb RCSB], [https://www.ebi.ac.uk/pdbsum/2wbb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wbb ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wbb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wbb OCA], [https://pdbe.org/2wbb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wbb RCSB], [https://www.ebi.ac.uk/pdbsum/2wbb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wbb ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
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[[https://www.uniprot.org/uniprot/F16P1_HUMAN F16P1_HUMAN]] Defects in FBP1 are the cause of fructose-1,6-bisphosphatase deficiency (FBPD) [MIM:[https://omim.org/entry/229700 229700]]. FBPD is inherited as an autosomal recessive disorder mainly in the liver and causes life-threatening episodes of hypoglycemia and metabolic acidosis (lactacidemia) in newborn infants or young children.<ref>PMID:9382095</ref> <ref>PMID:12126934</ref>
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[https://www.uniprot.org/uniprot/F16P1_HUMAN F16P1_HUMAN] Defects in FBP1 are the cause of fructose-1,6-bisphosphatase deficiency (FBPD) [MIM:[https://omim.org/entry/229700 229700]. FBPD is inherited as an autosomal recessive disorder mainly in the liver and causes life-threatening episodes of hypoglycemia and metabolic acidosis (lactacidemia) in newborn infants or young children.<ref>PMID:9382095</ref> <ref>PMID:12126934</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/F16P1_HUMAN F16P1_HUMAN]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Fructose-bisphosphatase]]
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[[Category: Homo sapiens]]
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[[Category: Human]]
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[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Benz, J]]
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[[Category: Alvarez Sanchez R]]
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[[Category: Bernadeau, A]]
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[[Category: Benz J]]
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[[Category: Fol, B]]
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[[Category: Bernadeau A]]
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[[Category: Gubler, M]]
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[[Category: Fol B]]
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[[Category: Haap, W]]
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[[Category: Gubler M]]
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[[Category: Hebeisen, P]]
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[[Category: Haap W]]
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[[Category: Huber, W]]
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[[Category: Hebeisen P]]
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[[Category: Joseph, C]]
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[[Category: Huber W]]
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[[Category: Kitas, E]]
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[[Category: Joseph C]]
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[[Category: Kuhn, B]]
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[[Category: Kitas E]]
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[[Category: Mohr, P]]
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[[Category: Kuhn B]]
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[[Category: Paehler, A]]
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[[Category: Mohr P]]
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[[Category: Ruf, A]]
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[[Category: Paehler A]]
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[[Category: Sanchez, R Alvarez]]
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[[Category: Ruf A]]
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[[Category: Schott, B]]
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[[Category: Schott B]]
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[[Category: Tetaz, T]]
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[[Category: Tetaz T]]
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[[Category: Tozzo, E]]
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[[Category: Tozzo E]]
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[[Category: Wessel, H P]]
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[[Category: Wessel HP]]
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[[Category: Allosteric enzyme]]
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[[Category: Carbohydrate metabolism]]
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[[Category: Gluconeogenesis]]
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[[Category: Hydrolase]]
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[[Category: Phosphoric monoester]]
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Current revision

FRUCTOSE-1,6-BISPHOSPHATASE(D-FRUCTOSE-1,6-BISPHOSPHATE-1- PHOSPHOHYDROLASE) (E.C.3.1.3.11) COMPLEXED WITH AN AMP SITE INHIBITOR

PDB ID 2wbb

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