2wd9

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Current revision (15:52, 13 December 2023) (edit) (undo)
 
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<StructureSection load='2wd9' size='340' side='right'caption='[[2wd9]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
<StructureSection load='2wd9' size='340' side='right'caption='[[2wd9]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2wd9]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WD9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WD9 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2wd9]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WD9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WD9 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IBP:IBUPROFEN'>IBP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2vze|2vze]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IBP:IBUPROFEN'>IBP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Butyrate--CoA_ligase Butyrate--CoA ligase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.2.1.2 6.2.1.2] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wd9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wd9 OCA], [https://pdbe.org/2wd9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wd9 RCSB], [https://www.ebi.ac.uk/pdbsum/2wd9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wd9 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wd9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wd9 OCA], [https://pdbe.org/2wd9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wd9 RCSB], [https://www.ebi.ac.uk/pdbsum/2wd9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wd9 ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ACS2A_HUMAN ACS2A_HUMAN] Has medium-chain fatty acid:CoA ligase activity with broad substrate specificity (in vitro). Acts on acids from C(4) to C(11) and on the corresponding 3-hydroxy- and 2,3- or 3,4-unsaturated acids (in vitro) (By similarity).
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Butyrate--CoA ligase]]
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[[Category: Homo sapiens]]
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[[Category: Human]]
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[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Arrowsmith, C H]]
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[[Category: Arrowsmith CH]]
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[[Category: Bhatia, C]]
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[[Category: Bhatia C]]
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[[Category: Bountra, C]]
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[[Category: Bountra C]]
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[[Category: Delft, F von]]
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[[Category: Edwards AM]]
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[[Category: Edwards, A M]]
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[[Category: Kochan GT]]
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[[Category: Kochan, G T]]
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[[Category: Oppermann U]]
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[[Category: Oppermann, U]]
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[[Category: Pilka ES]]
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[[Category: Pilka, E S]]
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[[Category: Weigelt J]]
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[[Category: Weigelt, J]]
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[[Category: Yue WW]]
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[[Category: Yue, W W]]
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[[Category: Von Delft F]]
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[[Category: Atp-binding]]
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[[Category: Fatty acid metabolic process]]
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[[Category: Fatty acid metabolism]]
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[[Category: Ligase]]
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[[Category: Ligase activity]]
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[[Category: Lipid metabolism]]
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[[Category: Magnesium]]
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[[Category: Medium-chain fatty acid]]
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[[Category: Metal-binding]]
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[[Category: Mitochondrion]]
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[[Category: Nucleotide binding]]
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[[Category: Nucleotide-binding]]
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[[Category: Transit peptide]]
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Current revision

CRYSTAL STRUCTURE OF HUMAN ACYL-COA SYNTHETASE MEDIUM-CHAIN FAMILY MEMBER 2A (L64P MUTATION) IN COMPLEX WITH IBUPROFEN

PDB ID 2wd9

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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