2wgh

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Current revision (15:55, 13 December 2023) (edit) (undo)
 
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<StructureSection load='2wgh' size='340' side='right'caption='[[2wgh]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
<StructureSection load='2wgh' size='340' side='right'caption='[[2wgh]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2wgh]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WGH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WGH FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2wgh]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WGH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WGH FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DTP:2-DEOXYADENOSINE+5-TRIPHOSPHATE'>DTP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Ribonucleoside-diphosphate_reductase Ribonucleoside-diphosphate reductase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.17.4.1 1.17.4.1] </span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DTP:2-DEOXYADENOSINE+5-TRIPHOSPHATE'>DTP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wgh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wgh OCA], [https://pdbe.org/2wgh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wgh RCSB], [https://www.ebi.ac.uk/pdbsum/2wgh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wgh ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wgh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wgh OCA], [https://pdbe.org/2wgh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wgh RCSB], [https://www.ebi.ac.uk/pdbsum/2wgh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wgh ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/RIR1_HUMAN RIR1_HUMAN]] Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
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[https://www.uniprot.org/uniprot/RIR1_HUMAN RIR1_HUMAN] Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Ribonucleoside-diphosphate reductase]]
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[[Category: Arrowsmith CH]]
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[[Category: Arrowsmith, C H]]
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[[Category: Berglund H]]
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[[Category: Berg, S Van Den]]
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[[Category: Bountra C]]
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[[Category: Berglund, H]]
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[[Category: Collins R]]
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[[Category: Bountra, C]]
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[[Category: Edwards AM]]
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[[Category: Collins, R]]
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[[Category: Flodin S]]
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[[Category: Edwards, A M]]
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[[Category: Flores A]]
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[[Category: Flodin, S]]
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[[Category: Graslund S]]
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[[Category: Flores, A]]
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[[Category: Hammarstrom M]]
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[[Category: Graslund, S]]
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[[Category: Johansson A]]
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[[Category: Hammarstrom, M]]
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[[Category: Johansson I]]
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[[Category: Johansson, A]]
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[[Category: Karlberg T]]
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[[Category: Johansson, I]]
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[[Category: Kotenyova T]]
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[[Category: Karlberg, T]]
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[[Category: Kotzsch A]]
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[[Category: Kotenyova, T]]
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[[Category: Kragh-Nielsen T]]
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[[Category: Kotzsch, A]]
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[[Category: Moche M]]
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[[Category: Kragh-Nielsen, T]]
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[[Category: Nordlund P]]
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[[Category: Moche, M]]
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[[Category: Nyman T]]
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[[Category: Nordlund, P]]
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[[Category: Persson C]]
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[[Category: Nyman, T]]
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[[Category: Sagemark J]]
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[[Category: Persson, C]]
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[[Category: Schueler H]]
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[[Category: Sagemark, J]]
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[[Category: Schutz P]]
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[[Category: Schueler, H]]
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[[Category: Siponen MI]]
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[[Category: Schutz, P]]
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[[Category: Svensson L]]
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[[Category: Siponen, M I]]
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[[Category: Thorsell AG]]
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[[Category: Svensson, L]]
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[[Category: Tresaugues L]]
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[[Category: Thorsell, A G]]
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[[Category: Van Den Berg S]]
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[[Category: Tresaugues, L]]
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[[Category: Weigelt J]]
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[[Category: Weigelt, J]]
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[[Category: Welin RM]]
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[[Category: Welin, R M]]
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[[Category: Wisniewska M]]
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[[Category: Wisniewska, M]]
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[[Category: Allosteric enzyme]]
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[[Category: Atp-binding]]
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[[Category: Cytoplasm]]
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[[Category: Dna replication]]
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[[Category: Nucleotide-binding]]
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[[Category: Oxidoreductase]]
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[[Category: Polymorphism]]
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Current revision

Human Ribonucleotide reductase R1 subunit (RRM1) in complex with dATP and Mg.

PDB ID 2wgh

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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