2wi3
From Proteopedia
(Difference between revisions)
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<StructureSection load='2wi3' size='340' side='right'caption='[[2wi3]], [[Resolution|resolution]] 1.90Å' scene=''> | <StructureSection load='2wi3' size='340' side='right'caption='[[2wi3]], [[Resolution|resolution]] 1.90Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2wi3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[2wi3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WI3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WI3 FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9Å</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZZ3:4-METHYL-6-(METHYLSULFANYL)-1,3,5-TRIAZIN-2-AMINE'>ZZ3</scene></td></tr> |
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wi3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wi3 OCA], [https://pdbe.org/2wi3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wi3 RCSB], [https://www.ebi.ac.uk/pdbsum/2wi3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wi3 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wi3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wi3 OCA], [https://pdbe.org/2wi3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wi3 RCSB], [https://www.ebi.ac.uk/pdbsum/2wi3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wi3 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref> | |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Barril | + | [[Category: Barril X]] |
| - | [[Category: Borgognoni | + | [[Category: Borgognoni J]] |
| - | [[Category: Brough | + | [[Category: Brough PA]] |
| - | [[Category: Chene | + | [[Category: Chene P]] |
| - | [[Category: Davies | + | [[Category: Davies NGM]] |
| - | [[Category: Davis | + | [[Category: Davis B]] |
| - | [[Category: Drysdale | + | [[Category: Drysdale MJ]] |
| - | [[Category: Dymock | + | [[Category: Dymock B]] |
| - | [[Category: Eccles | + | [[Category: Eccles SA]] |
| - | [[Category: Fromont | + | [[Category: Fromont C]] |
| - | [[Category: Garcia-Echeverria | + | [[Category: Garcia-Echeverria C]] |
| - | [[Category: Hayes | + | [[Category: Hayes A]] |
| - | [[Category: Hubbard | + | [[Category: Hubbard RE]] |
| - | [[Category: Jordan | + | [[Category: Jordan AM]] |
| - | [[Category: Massey | + | [[Category: Massey A]] |
| - | [[Category: Merret | + | [[Category: Merret A]] |
| - | [[Category: Padfield | + | [[Category: Padfield A]] |
| - | [[Category: Parsons | + | [[Category: Parsons R]] |
| - | [[Category: Radimerski | + | [[Category: Radimerski T]] |
| - | [[Category: Raynaud | + | [[Category: Raynaud FI]] |
| - | [[Category: Robertson | + | [[Category: Robertson A]] |
| - | [[Category: Roughley | + | [[Category: Roughley SD]] |
| - | [[Category: Rugaard-Jensen | + | [[Category: Rugaard-Jensen M]] |
| - | [[Category: Schoepfer | + | [[Category: Schoepfer J]] |
| - | [[Category: Simmonite | + | [[Category: Simmonite H]] |
| - | [[Category: Surgenor | + | [[Category: Surgenor A]] |
| - | [[Category: Valenti | + | [[Category: Valenti M]] |
| - | [[Category: Walls | + | [[Category: Walls S]] |
| - | [[Category: Webb | + | [[Category: Webb P]] |
| - | [[Category: Wood | + | [[Category: Wood M]] |
| - | [[Category: Workman | + | [[Category: Workman P]] |
| - | [[Category: Wright | + | [[Category: Wright LM]] |
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Current revision
Orally Active 2-Amino Thienopyrimidine Inhibitors of the Hsp90 Chaperone
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Categories: Homo sapiens | Large Structures | Barril X | Borgognoni J | Brough PA | Chene P | Davies NGM | Davis B | Drysdale MJ | Dymock B | Eccles SA | Fromont C | Garcia-Echeverria C | Hayes A | Hubbard RE | Jordan AM | Massey A | Merret A | Padfield A | Parsons R | Radimerski T | Raynaud FI | Robertson A | Roughley SD | Rugaard-Jensen M | Schoepfer J | Simmonite H | Surgenor A | Valenti M | Walls S | Webb P | Wood M | Workman P | Wright LM
