2wjs

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Current revision (15:59, 13 December 2023) (edit) (undo)
 
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<StructureSection load='2wjs' size='340' side='right'caption='[[2wjs]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
<StructureSection load='2wjs' size='340' side='right'caption='[[2wjs]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2wjs]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WJS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WJS FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2wjs]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WJS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WJS FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1dyk|1dyk]], [[1okq|1okq]], [[1qu0|1qu0]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wjs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wjs OCA], [https://pdbe.org/2wjs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wjs RCSB], [https://www.ebi.ac.uk/pdbsum/2wjs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wjs ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wjs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wjs OCA], [https://pdbe.org/2wjs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wjs RCSB], [https://www.ebi.ac.uk/pdbsum/2wjs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wjs ProSAT]</span></td></tr>
</table>
</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/LAMA2_MOUSE LAMA2_MOUSE] Note=Defects in Lama2 are a cause of murine muscular dystrophy (dy2J).
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== Function ==
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[https://www.uniprot.org/uniprot/LAMA2_MOUSE LAMA2_MOUSE] Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Lk3 transgenic mice]]
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[[Category: Mus musculus]]
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[[Category: Carafoli, F]]
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[[Category: Carafoli F]]
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[[Category: Clout, N J]]
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[[Category: Clout NJ]]
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[[Category: Hohenester, E]]
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[[Category: Hohenester E]]
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[[Category: Basement membrane]]
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[[Category: Cell adhesion]]
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[[Category: Coiled coil]]
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[[Category: Disulfide bond]]
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[[Category: Extracellular matrix]]
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[[Category: Glycoprotein]]
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[[Category: Integrin]]
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[[Category: Laminin egf-like domain]]
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[[Category: Laminin g-like domain]]
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[[Category: Secreted]]
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Current revision

Crystal structure of the LG1-3 region of the laminin alpha2 chain

PDB ID 2wjs

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