2wjz

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Current revision (15:59, 13 December 2023) (edit) (undo)
 
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<StructureSection load='2wjz' size='340' side='right'caption='[[2wjz]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
<StructureSection load='2wjz' size='340' side='right'caption='[[2wjz]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2wjz]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_43589 Atcc 43589]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WJZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WJZ FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2wjz]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WJZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WJZ FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.601&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2a0n|2a0n]], [[1thf|1thf]], [[1kxj|1kxj]], [[1gpw|1gpw]], [[1k9v|1k9v]], [[1vh7|1vh7]], [[2w6r|2w6r]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wjz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wjz OCA], [https://pdbe.org/2wjz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wjz RCSB], [https://www.ebi.ac.uk/pdbsum/2wjz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wjz ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wjz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wjz OCA], [https://pdbe.org/2wjz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wjz RCSB], [https://www.ebi.ac.uk/pdbsum/2wjz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wjz ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/HIS6_THEMA HIS6_THEMA]] IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.[HAMAP-Rule:MF_01013] [[https://www.uniprot.org/uniprot/HIS5_THEMA HIS5_THEMA]] IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR.[HAMAP-Rule:MF_00278]
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[https://www.uniprot.org/uniprot/HIS6_THEMA HIS6_THEMA] IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.[HAMAP-Rule:MF_01013]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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==See Also==
==See Also==
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*[[Indole-3-glycerol phosphate synthase|Indole-3-glycerol phosphate synthase]]
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*[[IGPS 3D structures|IGPS 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Atcc 43589]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Babinger, K]]
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[[Category: Thermotoga maritima]]
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[[Category: Haeger, M C]]
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[[Category: Babinger K]]
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[[Category: Kuper, J]]
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[[Category: Haeger MC]]
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[[Category: List, F]]
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[[Category: Kuper J]]
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[[Category: Razeto, A]]
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[[Category: List F]]
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[[Category: Sterner, R]]
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[[Category: Razeto A]]
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[[Category: Vega, M C]]
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[[Category: Sterner R]]
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[[Category: Wilmanns, M]]
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[[Category: Vega MC]]
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[[Category: Amino-acid biosynthesis]]
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[[Category: Wilmanns M]]
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[[Category: Ammonia channel]]
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[[Category: Cyclase]]
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[[Category: Glutaminase]]
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[[Category: Histidine biosynthesis]]
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[[Category: Lyase-transferase complex]]
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Current revision

Crystal structure of (HisH) K181A Y138A mutant of imidazoleglycerolphosphate synthase (HisH HisF) which displays constitutive glutaminase activity

PDB ID 2wjz

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