1qgb

From Proteopedia

---

Revision as of 16:46, 12 November 2007

proteopedia linkproteopedia link

spinqualitylabelsall models 1qgb Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

SOLUTION STRUCTURE OF THE N-TERMINAL F1 MODULE PAIR FROM HUMAN FIBRONECTIN

Contents 1 Overview 2 Disease 3 About this Structure 4 Reference

Overview

Multiple sites within the N-terminal domain (1-5F1) of fibronectin have, been implicated previously in fibronectin matrix assembly, heparin, binding, and binding to cell surface proteins of pathogenic bacteria. The, solution structure of 1F1(2)F1, the N-terminal F1 module pair from human, fibronectin, has been determined using NMR spectroscopy. Both modules in, the pair conform to the F1 consensus fold. In 4F1(5)F1, the only other F1, module pair structure available, there is a well-defined intermodule, interface; in 1F1(2)F1, however, there is no detectable interface between, the modules. Comparison of the backbone 15N-{1H} NOE values for both, module pairs confirms that the longer intermodule sequence in 1F1(2)F1 is, flexible and that the stabilization of the 4F1 C-D loop observed in, 4F1(5)F1, as a result of the intermodule interface, is not observed in, 1F1(2)F1.

Disease

Known diseases associated with this structure: Ehlers-Danlos syndrome, type X, 225310 (1) OMIM:[135600]

About this Structure

1QGB is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Solution structure of the N-terminal F1 module pair from human fibronectin., Potts JR, Bright JR, Bolton D, Pickford AR, Campbell ID, Biochemistry. 1999 Jun 29;38(26):8304-12. PMID:10387076

Page seeded by OCA on Mon Nov 12 18:52:55 2007