This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1qgk

From Proteopedia

(Difference between revisions)
Jump to: navigation, search

OCA (Talk | contribs)
(New page: 200px<br /> <applet load="1qgk" size="450" color="white" frame="true" align="right" spinBox="true" caption="1qgk, resolution 2.5&Aring;" /> '''STRUCTURE OF IMPORTI...)
Next diff →

Revision as of 16:46, 12 November 2007

Image:1qgk.gif

1qgk, resolution 2.5Å

Drag the structure with the mouse to rotate

STRUCTURE OF IMPORTIN BETA BOUND TO THE IBB DOMAIN OF IMPORTIN ALPHA

Overview

Cytosolic proteins bearing a classical nuclear localization signal enter, the nucleus bound to a heterodimer of importin-alpha and importin-beta, (also called karyopherin-alpha and -beta). The formation of this, heterodimer involves the importin-beta-binding (IBB) domain of, importin-alpha, a highly basic amino-terminal region of roughly 40, amino-acid residues. Here we report the crystal structure of human, importin-beta bound to the IBB domain of importin-alpha, determined at 2.5, A and 2.3 A resolution in two crystal forms. Importin-beta consists of 19, tandemly repeated HEAT motifs and wraps intimately around the IBB domain., The association involves two separate regions of importin-beta, recognizing structurally distinct parts of the IBB domain: an, amino-terminal extended moiety and a carboxy-terminal helix. The structure, indicates that significant conformational changes occur when importin-beta, binds or releases the IBB domain domain and suggests how dissociation of, the importin-alpha/beta heterodimer may be achieved upon nuclear entry.

About this Structure

1QGK is a Protein complex structure of sequences from Homo sapiens. The following page contains interesting information on the relation of 1QGK with [Importins]. Full crystallographic information is available from OCA.

Reference

Structure of importin-beta bound to the IBB domain of importin-alpha., Cingolani G, Petosa C, Weis K, Muller CW, Nature. 1999 May 20;399(6733):221-9. PMID:10353244

Page seeded by OCA on Mon Nov 12 18:52:57 2007

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1qgk"
Personal tools